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Synthesis 2007(18): 2835-2838
DOI: 10.1055/s-2007-983839
DOI: 10.1055/s-2007-983839
PAPER
© Georg Thieme Verlag Stuttgart · New York
Covalently Anchored Sulfonic Acid on Silica Gel as an Efficient and Reusable Heterogeneous Catalyst for the One-Pot Synthesis of Hantzsch 1,4-Dihydropyridines under Solvent-Free Conditions
Weitere Informationen
Received
18 April 2007
Publikationsdatum:
08. August 2007 (online)
Publikationsverlauf
Publikationsdatum:
08. August 2007 (online)
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Abstract
A highly efficient one-pot synthesis of Hantzsch 1,4-dihydropyridines under solvent-free conditions catalyzed by sulfonic acid covalently anchored onto the surface of silica gel is reported here. All types of aldehydes, including aromatic, unsaturated, and heterocyclic aldehydes, gave excellent yields. The silica gel/sulfonic acid catalyst (SiO2-SO3H) is completely heterogeneous and can be recycled for eight consecutive runs without significant loss of activity.
Key words
1,3-dicarbonyl compounds - supported catalysis - 1,4-dihydropyridines - heterogeneous catalysis - solvent-free conditions
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