Kinetic Resolution of Pyridyl Alcohols by Cu(II)(Borabox)-Catalyzed Acylation

Abstract

Kinetic resolution of pyridyl alcohols has been achieved using copper(II)(borabox)-catalyzed benzoylation. Selectivity factors (k_rel) of up to 125 have been observed and application to the synthesis of chiral pyridyl phosphine ligands is described.

Key words

kinetic resolution - asymmetric catalysis - copper - bisoxazoline ligands - pyridines

References

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7

Benzoyl chloride has been identified as the optimal acylating reagent for kinetic resolution of 1,2-diols. See reference 6b.