Solid-Phase Synthesis of 1,3,6-Trisubstituted Uracils Using Selenium-Bound Resin

Xian Huang; Jian Cao

doi:10.1055/s-2007-983886

PAPER

Solid-Phase Synthesis of 1,3,6-Trisubstituted Uracils Using Selenium-Bound Resin

Xian Huang*^a,b, Jian Cao^a
^a Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. of China
^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
Fax: +86(571)88807077; e-Mail: huangx@mail.hz.zj.cn;

Abstract

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Abstract

A novel procedure for the solid-phase synthesis of 1,3,6-trisubstituted uracils using a polymer-supported selenium resin is described. The advantages of the new method are good yields, high purity, straightforward operations, broad range and high diversity of the products, lack of odor, and good stability of the resins.

Key words

uracil - polymer-supported selenium resin - solid-phase synthesis - oxidative cleavage

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References

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