A New Route to 6-Substituted Pyrrolo[2,1-b]thiazoles from Morita-Baylis-Hillman Adducts of Thiazole-2-carboxaldehyde

Young Seok Song; Kee-Jung Lee

doi:10.1055/s-2007-983887

PAPER

A New Route to 6-Substituted Pyrrolo[2,1-b]thiazoles from Morita-Baylis-Hillman Adducts of Thiazole-2-carboxaldehyde

Young Seok Song, Kee-Jung Lee*
Organic Synthesis Laboratory, Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea
Fax: +82(2)22984101; e-Mail: leekj@hanyang.ac.kr;

Abstract

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Abstract

A simple synthesis of pyrrolo[2,1-b]thiazoles from the thermal cyclization reaction of several Morita-Baylis-Hillman acetates of thiazole-2-carboxaldehyde has been described.

Key words

pyrrolo[2,1-b]thiazoles - thiazole-2-carboxaldehyde - Morita-Baylis-Hillman acetate - thermal cyclization reaction

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Referenzen

References

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15

The MBH acetate of 1-methyl-1H-imidazole-2-carbox-aldehyde was too unstable to be isolated. Also, the decom-position products were obtained in refluxing Ph₂O.

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17

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