A Simplified Approach to N- and N,N′-Linked 1,2,4-Triazoles by Transamination

Anil D. Naik; Jacqueline Marchand-Brynaert; Yann Garcia

doi:10.1055/s-2007-983896

PSP

A Simplified Approach to N- and N,N′-Linked 1,2,4-Triazoles by Transamination

Anil D. Naik^a, Jacqueline Marchand-Brynaert^b, Yann Garcia*^a
^a Unité de Chimie des Matériaux Inorganiques et Organiques, Département de Chimie, Faculté des Sciences, Université Catholique de Louvain, Place L. Pasteur 1, 1348 Louvain-la-Neuve, Belgium
^b Unité de Chimie Organique et Médicinale, Département de Chimie, Faculté des Sciences, Université Catholique de Louvain, Place L. Pasteur 1, 1348 Louvain-la-Neuve, Belgium
Fax: +32(10)472330; e-Mail: garcia@chim.ucl.ac.be;

Abstract

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Abstract

A facile one-step procedure for the preparation of 4,4′-bis-1,2,4-triazole is reported. Direct transamination of N,N-dimethylformamide azine dihydrochloride by heating with 4-amino-1,2,4-triazole in refluxing benzene readily yields the target molecule in short duration of time with significant yield (73%). This catalyst-free method was extended to synthesise a series of 4-substituted 1,2,4-triazoles of potential interest in coordination chemistry.

Key words

amines - amino acids - ligands - transamination - 4,4′-bis-1,2,4-triazole

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