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Synthesis 2007(19): 3013-3016
DOI: 10.1055/s-2007-983898
DOI: 10.1055/s-2007-983898
PAPER
© Georg Thieme Verlag Stuttgart · New York
Efficient Synthesis of Iminoctadine, a Potent Antifungal Agent and Polyamine Oxidase Inhibitor (PAO)
Weitere Informationen
Received
29 May 2007
Publikationsdatum:
11. September 2007 (online)
Publikationsverlauf
Publikationsdatum:
11. September 2007 (online)
Abstract
Iminoctadine (1,17-diguanidino-9-azaheptadecane), isolated from a mixture of polyamines and guanidines known as guazatine that is used in agriculture as a fungicide, showed interesting activity as human antifungal agent and PAO inhibitor. In this paper, we propose a straightforward synthetic strategy for obtaining pure iminoctadine tris(trifluoroacetate) in high overall yield.
Key words
guazatine - antifungal agent - Candida albicans - polyamine oxidase inhibitor
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