Effect of Prolonged Training Period on Plasma Adiponectin in Elite Male Rowers

Abstract

Adiponectin is secreted by adipocytes and has been implicated in the regulation of energy homeostasis. Vigorous training program represents a physical stress condition in which heavy changes in energy expenditure might increase adiponectin concentration in athletes. Therefore, the aim of the present study was to investigate if there are changes in fasting adiponectin concentration during preparatory period in elite male rowers. Twelve rowers (mean and SD; age: 20.8±3.0 years; height: 192.9±4.7 cm; body mass: 91.9±5.3 kg; body fat percentage: 11.9±1.4%) were tested seven times over a 24-week training season. In addition to adiponectin, leptin, insulin, growth hormone, and glucose values were evaluated. Maximal oxygen consumption (VO_{2 max}) and aerobic power (Pa_max) were determined before and after the training period. Training was mainly organized as low-intensity prolonged training. Significant increases in VO_{2 max} (by 3.2±1.8%; from 6.2±0.5 to 6.4±0.4 l/min), VO_{2 max/kg} (by 2.2±2.0%; from 67.9±3.0 to 69.4±3.0 ml/min/kg) and Pa_max (by 4.6±6.3%; from 444.6±39.1 to 465.8±25.0 W) were observed after the 24-week period. All measured body compositional values were similar to pretraining values after the training period. Fasting adiponectin did not change during the preparatory period. Likewise, leptin, insulin, growth hormone, and glucose values were not significantly changed after the training period. Adiponectin concentration was significantly correlated (all p<0.05) with body mass (r=-0.40), body fat mass (r=-0.33), body fat free mass (r=0.38), and leptin (r=-0.31) values. In conclusion, fasting adiponectin does not change throughout the prolonged training period in elite male rowers despite substantial changes in training volume. Further studies are needed to clarify possible mechanisms by which adiponectin might influence energy homeostasis during heavy training in elite athletes.

Adiponectin - leptin - prolonged training - elite athletes

References

• 1 Esposito K, Pontillo A, Palo C Di, Giugliano G, Masella M, Marfella R, Giugliano D. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women.  JAMA. 2003;  289 1799-1804
• 2 Ferguson MA, White LJ, MacCoy S, Kim HW, Petty T, Wilsey J. Plasma adiponectin response to acute exercise in healthy subjects.  Eur J Appl Physiol. 2004;  91 324-329
• 3 Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, Sinha MK, Pories WJ, MacDonald KG, Dohm GL. Adiponectin is not altered with exercise training despite enhanced insulin action.  Am J Physiol Endocrinol Metab. 2002;  283 E861-E865
• 4 Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat.  Acta Physiol Scand. 2005;  184 285-293
• 5 MacMurray RG, Hackney AC. Interactions of metabolic hormones, adipose tissue and exercise.  Sports Med. 2005;  35 393-412
• 6 Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia.  J Clin Endocrinol Metab. 2001;  86 1930-1935
• 7 Bodou P, Sobngwi E, Mauvais-Jarvis F, Vexiau P, Gautier JF. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men.  Eur J Endocrinol. 2003;  149 421-424
• 8 Jürimäe J, Mäestu J, Jürimäe T. Leptin as a marker of training stress in highly trained male rowers?.  Eur J Appl Physiol. 2003;  90 533-538
• 9 Mäestu J, Jürimäe J, Jürimäe T. Hormonal reactions during heavy training stress and following tapering in highly trained male rowers.  Horm Metab Res. 2003;  35 109-113
• 10 Yamauchi M, Kamon J, Waki H. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.  Nat Med. 2001;  7 941-946
• 11 Fiskerstrand A, Seiler KS. Training and performance characteristics among Norwegian international rowers 1970-2001.  Scand J Med Sci Sports. 2004;  14 303-310
• 12 Mäestu J, Jürimäe J, Jürimäe T. Monitoring of performance and training in rowing.  Sports Med. 2005;  35 597-617
• 13 Simsch C, Lormes W, Petersen KG, Baur S, Liu Y, Hackney AC, Lehmann M, Steinacker JM. Training intensity influences leptin and thyroid hormones in highly trained rowers.  Int J Sports Med. 2002;  23 422-427
• 14 Segal KR, Loan M van, Fitzgerald PL, Hodgdon JA, Itallie TB van. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study.  Am J Clin Nutr. 1988;  47 7-14
• 15 Jürimäe J, Hofmann P, Jürimäe T, Mäestu J, Purge P, Wonisch M, Pokan R, Duvillard SP von. Plasma adiponectin response to sculling exercise at individual anaerobic threshold in college level male rowers.  Int J Sports Med. 2006;  27 272-277
• 16 Sudi K, Jürimäe J, Payerl D, Pihl E, Möller R, Tafeit E, Jürimäe T. Relationship between subcutaneous fatness and leptin in male athletes.  Med Sci Sports Exerc. 2001;  33 1324-1329
• 17 Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A, Nakai Y, Ishibashi S. Hypoadiponectemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.  Metabolism. 2003;  52 1274-1278
• 18 Noland RC, Baker JT, Boudreau SR, Kobe RW, Tanner CJ, Hickner RC, MacCammon MR, Houmard JA. Effect of intense training on plasma leptin in male and female swimmers.  Med Sci Sports Exerc. 2001;  33 227-231
• 19 Bobbert T, Weigewitz U, Brechtel L, Freudenberg M, Mai K, Möhlig M, Diedrich S, Ristow M, Rochlitz H, Pfeiffer AFH, Spranger J. Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulin sensitivity.  Int J Sports Med. 2007;  28 1-8
• 20 Jürimäe J, Purge P, Jürimäe T. Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers.  Metabolism. 2006;  55 13-19
• 21 Hotta K, Funahashi T, Arita Y, Takashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.  Arterioscler Thromb Vasc Biol. 2000;  20 1595-1599
• 22 Hulver MW, Saleh O, MacDonald KG, Pories WJ, Barakat HA. Ethnic differences in adiponectin levels.  Metabolism. 2004;  53 1-3
• 23 Jürimäe J, Rembel K, Jürimäe T, Rehand M. Adiponectin is associated with bone mineral density in perimenopausal women.  Horm Metab Res. 2005;  37 297-302
• 24 Thong FS, MacLean C, Graham TE. Plasma leptin in female athletes: relationship with body fat, reproductive, nutritional, and endocrine factors.  J Appl Physiol. 2000;  88 2037-2044
• 25 Niswener KD, Baskin DG, Shwartz MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis.  Trends Endocrinol Metab. 2004;  15 362-369
• 26 Brüning JC, Gautam D, Burks DJ. Role of brain insulin receptor in control of body weight and reproduction.  Science. 2000;  289 2122-2125
• 27 Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.  Biochem Biophys Res Commun. 2002;  290 1084-1089

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