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Semin Reprod Med 2007; 25(5): 305-312
DOI: 10.1055/s-2007-984736
Published in 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Gonadotropin-Releasing Hormone Neuronal Migration

Gerald A. Schwarting1 , Margaret E. Wierman2 , Stuart A. Tobet3
  • 1Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Waltham, Massachusetts
  • 2Department of Medicine, University of Colorado in Denver Health Science Center, Aurora, Colorado, and Research Service Veterans Administration Medical Center, Denver, Colorado
  • 3Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
Further Information

Publication History

Publication Date:
20 August 2007 (online)

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ABSTRACT

Neurons that synthesize and secrete the decapeptide gonadotropin-releasing hormone-1 (GnRH-1) to control the reproductive axis originate in the olfactory placode/vomeronasal organ of the olfactory system of mammals and migrate along vomeronasal nerves to the cribriform plate, which marks the boundary between the peripheral olfactory system and the forebrain. Migrating GnRH-1 neurons follow a branch of the vomeronasal nerve caudally into the hypothalamus, where they extend processes to the median eminence and halt their migration. The release of GnRH-1 into the capillaries of the median eminence starts the cascade that activates pituitary gonadotropin (luteinizing hormone and follicle-stimulating hormone) production and secretion. Failure of these neurons to complete their migration results in failure of the reproductive axis. In some cases, failed migration is linked to the loss of the sense of smell (anosmia). The mechanisms that regulate migration of GnRH-1 neurons along this complex pathway are incompletely understood. Recent studies have revealed an important role for a series of strategically located soluble factors that regulate different aspects of GnRH-1 neuron migration at specific locations along their migratory route. This review focuses on the different mechanisms used by these factors to regulate migration of GnRH-1 neurons.

KEYWORDS

SDF-1 - CXCR4 - kisspeptin - GPR54 - Kallmann syndrome

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Stuart A TobetPh.D. 

Department of Biomedical Sciences, Colorado State University

Fort Collins, CO 80523

Email: stuart.tobet@colostate.edu