Aktuelles zur Pflastertechnologie unter spezieller Berücksichtigung des Rotigotinpflasters

Zusammenfassung

Die kutane Applikation von Arzneistoffen hat in den vergangenen Jahren beträchtlich an Bedeutung gewonnen. Es lassen sich über diesen Weg unter Umgehung des First-past-Effektes kontrollierbare, konstante Blutspiegel erzielen, und die geringere Applikationshäufigkeit insbesondere mit transdermalen Pflastern wirkt sich positiv auf die Compliance aus. Der Wirkstoff Rotigotin bietet aufgrund seiner physikalisch-chemischen Eigenschaften wie hohe Lipophilie, niedriger Schmelzpunkt und damit gute Löslichkeit im Stratum corneum und dem niedrigen Molekulargewicht gute Voraussetzungen für die kutane Applikation mit angestrebter systemischer Wirkung.

Abstract

The cutaneous administration of drugs has considerably gained importance over the last years. By this route controlled, constant blood levels can be achieved, the first-pass effect can be avoided, and the lower application frequency, especially of transdermal patches, has a highly positive effect on compliance. On account of its physico-chemical properties such as high lipophilicity, low melting point and thus good solubility in the stratum corneum, as well as its low molecular weight, the drug rotigotine offers excellent prerequisites for cutaneous administration with a desired systemic action.

Schlüsselwörter

Matrix - kutane Penetration

Key words

matrix - cutaneous penetration

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