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DOI: 10.1055/s-2007-990237
© Georg Thieme Verlag KG Stuttgart · New York
Bioactive Capsular Polysaccharide from the Thermophilic Cyanophyte/Cyanobacterium Mastigocladus laminosus - Cytotoxic Properties
Publication History
Received: May 22, 2007
Revised: August 22, 2007
Accepted: September 8, 2007
Publication Date:
09 October 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/200713/lookinside/thumbnails/10.1055-s-2007-990237-1.jpg)
Abstract
The capsular polysaccharide produced by the thermophilic blue green alga/cyanobacterium Mastigocladus laminosus was tested for its cytotoxic activity against the A431 human epidermoid carcinoma cell line. This polysaccharide inhibited the proliferation of A431 cells in a dose-dependent manner with an IC50 value of 50 μg mL-1. In addition, this polysaccharide strongly inhibited A431 cell migration and invasion. Preliminary experiments showing that secretion of metalloproteinases MMP2 and MMP9 by A431 tumour cells was inhibited by this polysaccharide suggest that this mechanism of action could play a role in its anti-migration and anti-invasive properties. Acid hydrolysis of the polysaccharide produced specific oligosaccharides which conserved - at similar concentrations - their cytotoxic, anti-migration and anti-invasion properties; in this case, the mechanism of action was nevertheless uncorrelated to the decrease of metalloproteinase expression.
Key words
Mastigocladus laminosus - blue-green alga - cyanobacterium - capsular polysaccharide - carcinoma - cytotoxic properties
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Dr. Vincent Gloaguen
Laboratoire de Chimie des Substances Naturelles
Faculté des Sciences et Techniques
Université de Limoges
123 rue A. Thomas
87060 Limoges
France
Phone: +33-5-5545-7481
Email: vincent.gloaguen@unilim.fr