Planta Med 2007; 73(14): 1457-1463
DOI: 10.1055/s-2007-990263
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Structure-Activity Relationship of Triterpenes and Triterpenoid Glycosides against Tobacco Mosaic Virus

Zheng-Kun Zhang1 , Ming-An Ouyang1 , 3 , Zu-Jian Wu1 , 2 , Qi-Ying Lin1 , Lian-Hui Xie1 , 2
  • 1Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P. R. China
  • 2Key Laboratory of Bio-pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P. R. China
  • 3Huaqiao University, Quanzhou, Fujian, P. R. China
Further Information

Publication History

Received: July 24, 2007 Revised: September 27, 2007

Accepted: October 5, 2007

Publication Date:
08 November 2007 (online)

Abstract

A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according to the results of bio-activity screening. Besides, the EC50 values of those compounds having higher activities were measured.

Abbreviations

Cpd(s):compound(s)

DMSO:dimethyl sulfoxide

EC50:median effective concentration

ELISA:enzyme linked immunosorbent assay

SAR:structure-activity relationship

TMV:tobacco mosaic virus

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Prof. Ming-An Ouyang

Institute of Plant Virology

Fujian Agriculture and Forestry University

Fuzhou

Fujian 350002

People’s Republic of China

Phone: +86-591-8379-3817

Email: maouyang@yahoo.com