Abstract
The reactive 1:1 zwitterionic intermediate formed by the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped by 3,6-dihydroxypyridazine to produce 3-amino-5,8-dioxo-5,8-dihydro-1H -pyrazolo[1,2-a ]pyridazines in good yields.
Key words
multicomponent reactions - pyrazolo[1,2-a ]pyridazines - isocyanides - cyclizations - heterocycles
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