Synthesis 2007(20): 3141-3146  
DOI: 10.1055/s-2007-990786
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Aliphatic Hydroxyaryl Ketones or (Hetero)aryl Hydroxyaryl Ketones by Acylation of Organometallic Reagents

Alan R. Katritzky*, Khanh N. B. Le, Prabhu P. Mohapatra
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Fax: +1(352)3929199; e-Mail: katritzky@chem.ufl.edu;
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Publikationsverlauf

Received 27 April 2007
Publikationsdatum:
21. September 2007 (online)

Abstract

Diverse hydroxyarenecarboxylic acids afford stable N-(hydroxyaroyl)benzotriazoles that react with heteroaryl, alkyl, and aryl Grignard or lithium reagents to give the corresponding hydroxyaryl ketones in 51-94% yields.