Chlorotrimethylsilane-Mediated Synthesis of Functionalized 2-(2-Hydroxybenzoyl)pyrido[1,2-a]benzimidazoles

Sergey V. Ryabukhin; Andrey S. Plaskon; Dmitriy M. Volochnyuk; Andrey A. Tolmachev

doi:10.1055/s-2007-990790

PAPER

Chlorotrimethylsilane-Mediated Synthesis of Functionalized 2-(2-Hydroxybenzoyl)pyrido[1,2-a]benzimidazoles

Sergey V. Ryabukhin^a,b, Andrey S. Plaskon^a,b, Dmitriy M. Volochnyuk*^a,c, Andrey A. Tolmachev^b
^a Enamine Ltd., 23 Alexandra Matrosova st., 01103 Kiev, Ukraine
^b National Taras Shevchenko University, 62 Volodymyrska st., 01033 Kiev, Ukraine
^c Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, 02094 Kiev, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;

Abstract

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Abstract

Heating 3-formylchromone with a variety of benzimidazoles and imidazoles in N,N-dimethylformamide in the presence of chlorotrimethylsilane as a promoter and water-scavenger gave functionalized pyrido[1,2-a]benzimidazoles and imidazo[1,2-a]pyridines.

Key words

3-formylchromone - benzimidazole - imidazole - pyrido[1,2-a]benzimidazole - imidazo[1,2-a]pyridine - recyclization - chlorotrimethylsilane

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References

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