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Synthesis 2007(21): 3385-3389
DOI: 10.1055/s-2007-990805
DOI: 10.1055/s-2007-990805
PAPER
© Georg Thieme Verlag Stuttgart · New York
One-Pot Microwave-Promoted Synthesis of Nitriles from Aldehydes via tert-Butanesulfinyl Imines
Further Information
Received
11 April 2007
Publication Date:
21 September 2007 (online)
Publication History
Publication Date:
21 September 2007 (online)
Abstract
A facile, one-pot method for the synthesis of nitriles from aldehydes via a microwave-promoted, concerted elimination of tert-butanesulfenic acid from tert-butanesulfinyl-protected imines, is described. The mild reaction conditions exhibit broad functional group compatibility and generate products in good isolated yield (69-87%). This method provides a rapid and mild procedure for the synthesis of various functionalized nitriles.
Key words
microwave - nitriles - aldehydes - tert-butanesulfinamide - tert-butanesulfinyl imine
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