Synthesis of Novel and Stable 5-Aminolevulinic Acid Derivatives for the Efficient Synthesis of 5-Aminolevulinic Acid Based Prodrugs

Ramakrishnan Vallinayagam; Hugo Bertschy; Yann Berger; Virginie Wenger; Reinhard Neier

doi:10.1055/s-2007-990825

PAPER

Synthesis of Novel and Stable 5-Aminolevulinic Acid Derivatives for the Efficient Synthesis of 5-Aminolevulinic Acid Based Prodrugs

Ramakrishnan Vallinayagam^a, Hugo Bertschy^b, Yann Berger^c, Virginie Wenger^a, Reinhard Neier*^a
^a Institut de Chimie, Université de Neuchâtel, Rue Emile-Argand, 11, PO 158, 2009 Neuchatel, Switzerland
Fax: +41(32)7182511; e-Mail: reinhard.neier@unine.ch;
^b c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland
^c c/o Laboratoire cantonal contrôle denrées alimentaires, Les Croisettes, Case postale 68, 1066 Epalinges, Switzerland

Abstract

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Abstract

The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chemical transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields.

Key words

amino acid - activated ester - protecting group - prodrug - porphyrin

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References

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11a

Ramakrishnan, V.; Schmitt, F.; Barge, J.; Wagnieres, G.; Wenger, V.; Neier, R.; Juillerat-Jeannerat, L. manuscript submitted.

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