A Simple and Efficient Synthesis of New Mono- and Bis([1,2,4]-oxadiazol)-benzaldehyde Building Blocks

Abstract

An efficient approach to bis([1,2,4]-oxadiazol)benzaldehydes as well as the corresponding mono-benzaldehyde derivatives has been developed starting from benzamidoxime, which is readily obtained from 4-cyanobenzaldehyde. All these new compounds were synthesized in a high-yielding, five-step procedure with few and simple purifications.

Key words

mono- and bis-benzaldehyde - 1,2,4-oxadiazole - benz­amidoxime - O-acylation - acetal deprotection

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