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Synthesis 2007(23): 3635-3638
DOI: 10.1055/s-2007-990852
DOI: 10.1055/s-2007-990852
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis and Characterization of Model Compounds for the Neutral Green Fluorescent Protein Chromophore
Weitere Informationen
Received
22 June 2007
Publikationsdatum:
29. Oktober 2007 (online)
Publikationsverlauf
Publikationsdatum:
29. Oktober 2007 (online)
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Abstract
Two new derivatives of the green fluorescent protein (GFP) chromophore each containing a charged substituent (CH2CH2NH3 + and CH2CH2NMe3 +, respectively) on the imidazolone ring have been prepared. These compounds are model systems for the neutral GFP chromophore with an unprotonated phenol moiety. The ammonium groups allow for electrospray ionization and the possibility to study the optical properties of the isolated chromophores in the gas phase. A derivative containing a CH2CH2OH substituent arm was also prepared.
Key words
amides - amines - chromophores - heterocycles - phenols
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