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Synthesis 2007(23): 3620-3626
DOI: 10.1055/s-2007-990870
DOI: 10.1055/s-2007-990870
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of 4(5)-Acyl-2-aminoimidazoles and Vinylogues
Further Information
Received
1 June 2007
Publication Date:
31 October 2007 (online)
Publication History
Publication Date:
31 October 2007 (online)
Abstract
A convenient protocol for the preparation of 4(5)-acyl-2-aminoimidazoles and vinylogues is disclosed employing a crystalline imidazole-derived iminophosphorane as the coupling partner in Heck and Sonogashira reactions. For the first time, derivatives of urocanic acid bearing a free amino group in the 2′-position are described.
Key words
aminoimidazole - iminophosphorane - cross coupling - pyrrole-imidazole-alkaloids - alkyne hydration
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References
CCDC numbers: 644864 (2), 644865 (18).