Hepatic Microvasculature in Liver Injury

Laurie D. DeLeve

doi:10.1055/s-2007-991515

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2007; 27(4): 390-400
DOI: 10.1055/s-2007-991515

Hepatic Microvasculature in Liver Injury

Laurie D. DeLeve¹

¹Division of Gastrointestinal and Liver Diseases and the USC Research Center for Liver Diseases, University of Southern California, Keck School of Medicine, Los Angeles, California

Abstract

ABSTRACT

Injury to the hepatic microvasculature, the hepatic sinusoids, manifests in several ways. The sinusoidal endothelial cells (SECs) may lose porosity and scavenger function (capillarization); SECs may loosen from their tetherings to the space of Disse or even detach completely (ischemia-reperfusion injury, early sinusoidal obstruction syndrome, peliosis hepatis, early acetaminophen toxicity); the space of Disse may be completely denuded of sinusoidal lining cells that then embolize and obstruct the sinusoid (early sinusoidal obstruction syndrome); or the sinusoid may be obstructed by fibrosis (hepatic sinusoidal fibrosis, late sinusoidal obstruction syndrome). In many of these microvascular injuries, the change to the sinusoid is a primary event that may lead to hepatocyte hypoxia with liver dysfunction and disruption of the portal circulation. With the exception of hepatic fibrosis, which will be reviewed elsewhere in this issue, each of these types of microvascular injuries will be described in this article.

KEYWORDS

Endothelial cell - veno-occlusive disease - liver circulation - reperfusion injury - toxic hepatitis - liver fibrosis

Full Text

References

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Laurie D DeLeveM.D. Ph.D.

Division of Gastrointestinal and Liver Diseases and the USC Research Center for Liver Diseases, University of Southern California, Keck School of Medicine

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Email: deleve@usc.edu