Dopamine, Prefrontal Cortex and Working Memory Functioning in Schizophrenia

Abstract

Proposing working memory disturbances as one of the core symptoms of cognitive deficits in schizophrenia the authors summarize and discuss the dependency on prefrontal cortex functioning and working memory performance. On the basis of a strong association of prefrontal functioning and the dopaminergic system the authors refer to schizophrenia as an illustrative example. Altered dopamine function and associated working memory performance are discussed with regard to effects of psychopharmacological treatment to modulate cognitive processes.

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