ABSTRACT
There is substantial heterogeneity of symptoms and signs among women with polycystic ovary syndrome (PCOS). In addition to different diagnostic criteria used, the ethnic background of women with PCOS may affect the clinical, hormonal, and metabolic characteristics of this condition. We present here studies related to the clinical, hormonal, and metabolic characteristics and response to the treatment of PCOS in Asia, which may be different from those in Western countries. It is important to take into consideration the ethnic background of patients in future studies related to PCOS.
KEYWORDS
Asian women - ethnic origin - polycystic ovary syndrome
REFERENCES
-
1
Azziz R, Woods K S, Reyna R, Key T J, Knochenhauer E S, Yildiz B O.
The prevalence and features of the polycystic ovary syndrome in an unselected population.
J Clin Endocrinol Metab.
2004;
89
2745-2749
-
2
Franks S.
Polycystic ovary syndrome.
N Engl J Med.
1995;
333
853-861
-
3
The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group .
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.
Hum Reprod.
2004;
19
41-47
-
4
Adams J, Polson D W, Franks S.
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.
BMJ.
1986;
293
355-359
-
5
Balen A H, Laven J SE, Tan S L, Dewailly D.
Ultrasound assessment of the polycystic ovary: international consensus definitions.
Hum Reprod Update.
2003;
9
505-514
-
6
Taponen S, Ahonkallio S, Martikainen H et al..
Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 study.
Hum Reprod.
2004;
19
1083-1088
-
7
Rodin D A, Bano G, Bland J M, Taylor K, Nussey S S.
Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women.
Clin Endocrinol (Oxf).
1998;
49
91-99
-
8
Ng E HY, Fong D YT, Yeung W SB, Ho P C.
Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility.
Hum Reprod.
2003;
18
2169-2174
-
9
Ng E HY, Chan C CW, Yeung W SB, Ho P C.
Effect of age on ovarian stromal flow measured by three-dimensional ultrasound with power Doppler in Chinese women with proven fertility.
Hum Reprod.
2004;
19
2132-2137
-
10
Ng E HY, Chan C CW, Yeung W SB, Ho P C.
Antral follicle count and follicle stimulating hormone concentration after clomiphene citrate challenge test in the prediction of ovarian response during in vitro fertilization treatment.
Hum Reprod.
2005;
20
1647-1654
-
11
Chan C CW, Ng E HY, Tang O S, Lee C P, Ho P C.
The prevalence of polycystic ovary in Chinese women with a history of gestational diabetes.
Gynecol Endocrinol.
2006;
22
516-520
-
12
Yao L Q, Kuang J Q, Feng Y J, Yang D Z, Li L, Xu C J.
Characterization of unilateral polycystic ovary compared with polycystic ovary syndrome.
Fertil Steril.
2006;
85
805-808
-
13
Zaidi J, Campbell S, Pittrof R et al..
Ovarian stromal blood flow in women with polycystic ovaries-a possible new marker for diagnosis?.
Hum Reprod.
1995;
10
1992-1996
-
14
Agrawal R, Sladkevicius P, Engmann L et al..
Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries.
Hum Reprod.
1998;
13
651-655
-
15
Pairleitner H, Steiner H, Hasenoehrl G, Staudach A.
Three-dimensional power Doppler sonography: imaging and quantifying blood flow and vascularization.
Ultrasound Obstet Gynecol.
1999;
14
139-143
-
16
Pan H A, Wu M H, Cheng Y C, Li C H, Chang F M.
Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for diagnosis.
Hum Reprod.
2002;
17
201-206
-
17
Järvelä I Y, Mason H D, Sladkevicius P et al..
Characterization of normal and polycystic ovaries using three-dimensional power Doppler ultrasonography.
J Assist Reprod Genet.
2002;
19
582-590
-
18
Ng E HY, Chan C CW, Yeung W SB, Ho P C.
Comparison of ovarian stromal flow measured by three-dimensional power Doppler ultrasound between fertile women with normal ovaries and infertile women with polycystic ovary syndrome.
Hum Reprod.
2005;
20
1881-1886
-
19
Carmina E, Koyama T, Chang L, Stanczyk F Z, Lobo R A.
Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome?.
Am J Obstet Gynecol.
1992;
167
1807-1812
-
20
Norman R J, Mahabeer S, Masters S.
Ethnic differences in insulin and glucose response to glucose between white and Indian women with polycystic ovary syndrome.
Fertil Steril.
1995;
63
58-62
-
21
Wijeyaratne C N, Balen A H, Barth J H, Belchetz P E.
Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome PCOS) among South Asians and Caucasians: is there a difference?.
Clin Endocrinol (Oxf).
2002;
57
343-350
-
22
Chen X, Yang D, Li L, Feng S, Wang L.
Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome.
Hum Reprod.
2006;
21
2027-2032
-
23
Li L, Yang D, Chen X, Chen Y, Feng S, Wang L.
Clinical and metabolic features of polycystic ovary syndrome.
Int J Gynaecol Obstet.
2007;
97
129-134
-
24
Ng E HY, Chan C CW, Ho P C.
Are there differences in ultrasound parameters between women with polycystic ovaries only and with polycystic ovary syndrome?.
Eur J Obstet Gynecol Reprod Biol.
2006;
125
92-98
-
25
The ESHRE Capri Workshop .
Female infertility: treatment options for complicated cases.
Hum Reprod.
1997;
12
1191-1196
-
26
Takahashi K, Uchida A, Yamasaki H, Ozaki T, Kitao M.
Transvaginal ultrasonic assessment of the response to clomiphene citrate in polycystic ovarian syndrome.
Fertil Steril.
1994;
62
48-53
-
27
Kondoh Y, Uemura T, Ishikawa M, Yokoi N, Hirahara F.
Classification of polycystic ovary syndrome into three types according to response to human corticotropin-releasing hormone.
Fertil Steril.
1999;
72
15-20
-
28
Andoh K, Mizunuma H, Liu X, Kamijo T, Yamada K, Ibuki Y.
A comparative study of fixed-dose, step-down, and low-dose step-up regimens of human menopausal gonadotropin for patients with polycystic ovary syndrome.
Fertil Steril.
1998;
70
840-846
-
29
Dunaif A.
Insulin resistance and the polycystic ovary syndrome: mechanisms and implication for pathogenesis.
Endocr Rev.
1997;
18
774-800
-
30
Lord J M, Flight I HK, Norman R J.
Metformin in polycystic ovary syndrome: systematic review and meta-analysis.
BMJ.
2003;
327
951-953
-
31
Ng E HY, Wat W MS, Ho P C.
Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial.
Hum Reprod.
2001;
16
1625-1631
-
32
Moll E, Bossuyt P M, Korevaar J C, Lambalk C B, van der Veen F.
Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial.
BMJ.
2006;
332
1485-1489
-
33
Legro R S, Barnhart H X, Schlaff W D et al..
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
N Engl J Med.
2007;
356
551-566
-
34
Kiddy D S, Hamilton-Fairley D, Bush A et al..
Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome.
Clin Endocrinol (Oxf).
1992;
36
105-111
-
35
Han L K, Takaku T, Li J, Kimura Y, Okuda H.
Anti-obesity action of oolong tea.
Int J Obes Relat Metab Disord.
1999;
23
98-105
-
36
Kao Y H, Hiipakka R A, Liao S.
Modulation of endocrine systems and food intake by green tea epigallocatechin gallate.
Endocrinology.
2000;
141
980-987
-
37
Chantre P, Lairon D.
Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity.
Phytomedicine.
2002;
9
3-8
-
38
Dulloo A G, Duret C, Rohrer D et al..
Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.
Am J Clin Nutr.
1999;
70
1040-1045
-
39
Yang T TC, Koo M WL.
Hypocholesterolemic effects of Chinese tea.
Pharmacol Res.
1997;
35
505-512
-
40
Chan C CW, Koo M WL, Ng E HY, Tang O S, Yeung W SB, Ho P C.
Effects of Chinese green tea on weight, hormonal and biochemical profiles in obese patients with polycystic ovary syndrome - a randomized placebo controlled trial.
J Soc Gynecol Investig.
2006;
13
63-68
-
41
Imai K, Suga K, Nakachi K.
Cancer-preventive effects of drinking green tea among a Japanese population.
Prev Med.
1997;
26
769-775
-
42
Wang D Z, Wang Z Q, Shi L Y.
Treatment of polycystic ovary syndrome with Chinese drug longdan xiegan tang.
J Tradit Chin Med.
1988;
8
117-119
-
43
Takahashi K, Kitao M.
Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease.
Int J Fertil Menopausal Stud.
1994;
39
69-76
-
44
Sakai A, Kondo Z, Kamei K, Izumi S, Sumi K.
Induction of ovulation by Sairei-to for polycystic ovary syndrome patients.
Endocr J.
1999;
46
217-220
-
45
Ushiroyama T, Ikeda A, Sakai M et al..
Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion.
J Reprod Med.
2001;
6
451-456
-
46
Xiao B.
Chinese traditional medicine for induction of ovulation.
J Reprod Med.
2003;
12(Suppl 1)
1-8
-
47
Farquhar C, Lilford R J, Marjoribanks J, Vandekerckhove P.
Laparoscopic “drilling” by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome.
Cochrane Database Syst Rev.
2005;
3
CD001122
-
48
Wu X K, Su Y H, Zhang Z X.
Wedge resection to improve insulin resistance in polycystic ovary syndrome: a study among Chinese women.
Br J Obstet Gynaecol.
1996;
103
822-825
-
49
Zhu W, Li X, Chen X, Lin Z, Zhang L.
Ovarian interstitial YAG-laser: an effective new method to manage anovulation in women with polycystic ovary syndrome.
Am J Obstet Gynecol.
2006;
195
458-463
Ernest Hung Yu NgM.D.
Department of Obstetrics and Gynaecology, The University of Hong Kong
6/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
Email: nghye@hkucc.hku.hk
