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Semin Reprod Med 2008; 26(1): 121-126
DOI: 10.1055/s-2007-992932
© Thieme Medical Publishers

In Vitro Maturation for Patients with Polycystic Ovary Syndrome

Shauna L. Reinblatt1 , William Buckett1
  • 1Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
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Publication History

Publication Date:
08 January 2008 (online)

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ABSTRACT

In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome.

In vitro maturation (IVM) avoids the risks and side effects of ovarian stimulation by retrieving immature oocytes from unstimulated ovaries. These immature oocytes are then cultured, matured, and fertilized in vitro. Embryos are then selected for transfer in the same manner as conventional IVF. Although there has been significant progress in terms of improving clinical pregnancy and live-birth rates after IVM, there remains much to learn in terms of what controls maturation, fertilization, and implantation rates. This review is intended as an update on the most recent advances and directions of ongoing research in IVM in patients with PCOS.

KEYWORDS

Assisted reproductive technology - in vitro maturation - polycystic ovary syndrome

REFERENCES

  • 1 Child T J, Abdul-Jalil A K, Guleki B et al.. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries and women with polycystic ovary syndrome.  Fertil Steril. 2001;  76 936-942
    CrossrefPubMedGoogle Scholar
  • 2 MacDougall M J, Tan S L, Balen A et al.. A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization.  Hum Reprod. 1993;  8 233-237
    PubMedGoogle Scholar
  • 3 Ludwig M, Finas D F, Al-Hasani S et al.. Oocyte quality and treatment outcome in intracytoplasmic injection cycles of polycystic ovarian syndrome patients.  Hum Reprod. 1999;  14 354-358
    CrossrefPubMedGoogle Scholar
  • 4 Cha K Y, Koo J J, Ko J J et al.. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program.  Fertil Steril. 1991;  55 109-113
    PubMedGoogle Scholar
  • 5 Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients.  Fertil Steril. 1994;  62 353-362
    PubMedGoogle Scholar
  • 6 Andersen A N, Gianaroli L, Felberbaum R et al.. Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE.  Hum Reprod. 2007;  22 1513-1525
    CrossrefPubMedGoogle Scholar
  • 7 SART .National statistics for ART. http://Available at: www.sartonline.com
    Google Scholar
  • 8 Tan S L, Child T J, Guleki B. In vitro maturation and fertilization of oocytes from unstimulated ovaries: predicting the number of immature oocytes retrieved by early follicular phase ultrasonography.  Am J Obstet Gynecol. 2002;  186 684-689
    CrossrefPubMedGoogle Scholar
  • 9 Rao G D, Tan S L. In vitro maturation of oocytes.  Semin Reprod Med. 2005;  23 242-247
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Al-Sunaidi M, Tulandi T, Holzer H et al.. Repeated pregnancies and live births after in vitro maturation treatment.  Fertil Steril. 2007;  87 1212. e9-e12
    PubMedGoogle Scholar
  • 11 Chian R C, Buckett W M, Tulandi T et al.. Prospective randomized study of human chorionic gonadotrophin priming before immature oocyte retrieval from unstimulated women with polycystic ovarian syndrome.  Hum Reprod. 2000;  15 165-170
    CrossrefPubMedGoogle Scholar
  • 12 Chian R C, Buckett W M, Too L L et al.. Pregnancies resulting from in vitro matured oocytes retrieved from patients with polycystic ovary syndrome after priming with human chorionic gonadotropin.  Fertil Steril. 1999;  72 639-642
    CrossrefPubMedGoogle Scholar
  • 13 Lin Y H, Hwang J L, Huang L W et al.. Combination of FSH priming and HCG priming for in-vitro maturation of human oocytes.  Hum Reprod. 2003;  18 1632-1636
    CrossrefPubMedGoogle Scholar
  • 14 Chian R C, Guleki B, Buckett W M et al.. Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome.  N Engl J Med. 1999;  341 1624-1626
    CrossrefPubMedGoogle Scholar
  • 15 Son W Y, Yoon S H, Lim J H. Effect of gonadotropin priming on in-vitro maturation of oocytes collected from women at risk of OHSS.  Reprod Biomed Online. 2006;  13 340-348
    CrossrefPubMedGoogle Scholar
  • 16 Chian R C. In-vitro maturation of immature oocytes for infertile women with PCOS.  Reprod Biomed Online. 2004;  8 547-552
    CrossrefPubMedGoogle Scholar
  • 17 Soderstrom-Anttila V, Makinen S, Tuuri T et al.. Favourable pregnancy rates with insemination of in vitro matured oocytes from unstimulated patients.  Hum Reprod. 2005;  20 1534-1540
    CrossrefPubMedGoogle Scholar
  • 18 Mikkelsen A L, Lindenberg S. Benefit of FSH priming of women with PCOS to the in vitro maturation procedure and the outcome: a randomized prospective study.  Reproduction. 2001;  122 587-592
    PubMedGoogle Scholar
  • 19 Requena A, Neuspiller F, Cobo A C et al.. Endocrinological and ultrasonographic variations after immature oocyte retrieval in a natural cycle.  Hum Reprod. 2001;  16 1833-1837
    CrossrefPubMedGoogle Scholar
  • 20 Child T J, Guleki B, Sylvestre C et al.. Ultrasonographic assessment of endometrial receptivity at embryo transfer in an in vitro maturation of oocyte program.  Fertil Steril. 2003;  79 656-658
    CrossrefPubMedGoogle Scholar
  • 21 Noyes N, Liu H C, Schattman G et al.. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization.  Hum Reprod. 1995;  10 919-922
    PubMedGoogle Scholar
  • 22 Chian R C, Buckett W M, Tan S L. In-vitro maturation of human oocytes.  Reprod Biomed Online. 2004;  8 148-166
    CrossrefPubMedGoogle Scholar
  • 23 Tan S L, Child T J. In vitro maturation of oocytes from unstimulated polycystic ovaries.  Reprod Biomed Online. 2001;  4(Suppl 1) 18-23
    PubMedGoogle Scholar
  • 24 Child T J, Phillips S J, Abdul-Jalil A K et al.. A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries.  Obstet Gynecol. 2002;  100 665-670
    CrossrefPubMedGoogle Scholar
  • 25 Le Du A, Kadoch I J, Bourcigaux N et al.. in vitro maturation fro the treatment of infertility associated with polycystic ovarian syndrome: the French experience.  Hum Reprod. 2005;  20 420-424
    CrossrefPubMedGoogle Scholar
  • 26 Papanikolaou E G, Platteau P, Albano C et al.. Immature oocyte in-vitro maturation: clinical aspects.  Reprod Biomed Online. 2005;  10 587-592
    PubMedGoogle Scholar
  • 27 Cha K Y, Chung H M, Lee D R et al.. Obstetric outcome of patients with polycystic ovary syndrome treated by in vitro maturation and in vitro fertilization-embryo transfer.  Fertil Steril. 2005;  83 1461-1465
    CrossrefPubMedGoogle Scholar
  • 28 Soderstrom-Anttila V, Salokorpi T, Pihlaja M et al.. Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes.  Hum Reprod. 2006;  21 1508-1513
    CrossrefPubMedGoogle Scholar
  • 29 Buckett W, Chian R C, Holzer H et al.. Congenital abnormalities and perinatal outcome in pregnancies following IVM, IVF, and ICSI delivered in a single center.  Fertil Steril. 2006;  85(Suppl 2) s11-s12 , (abst)
    CrossrefPubMedGoogle Scholar
  • 30 Li Y, Feng H L, Cao Y J et al.. Confocal microscopic analysis of the spindle and chromosome configurations of human oocytes matured in vitro.  Fertil Steril. 2006;  85 827-832
    CrossrefPubMedGoogle Scholar

William BuckettM.D. 

Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital

687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada

Email: william.buckett@muhc.mcgill.ca