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DOI: 10.1055/s-2007-993075
© Georg Thieme Verlag Stuttgart · New York
Therapie der chronischen myeloischen Leukämie - Ziel ist die hämatologische und zytogenetische Remission
Therapy of chronic myeloid leukaemia - Aiming at haematologic and cytogenetic remissionPublication History
Publication Date:
31 October 2007 (online)
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Die gesamte Therapie und auch die Prognose der Patienten mit chronischer myeloischer Leukämie (CML) hat sich seit Einführung des Tyrosinkinaseinhibitors Imatinib entscheidend verbessert. So gibt es inzwischen für die Behandlung von Patienten in der chronischen Phase der Erkrankung wissenschaftlich gut fundierte Empfehlungen zum Einsatz dieses Medikaments. Bei Unverträglichkeit oder Unwirksamkeit von Imatinib können alternativ Dasatinib oder Nilotinib, zwei weitere Substanzen aus der Klasse der Tyrosinkinaseinhibitoren, eingesetzt werden. In fortgeschrittenen Krankheitsstadien ist die jeweilige Vortherapie für eine Therapieentscheidung zu berücksichtigen. Grundsätzlich gilt jedoch, dass CML-Patienten die Teilnahme an klinischen Studien empfohlen werden sollte.
Both the treatment strategy and the prognosis of patients with chronic myeloid leukaemia (CML) has significantly improved since the introduction of the tyrosine kinase inhibitor imatinib. For patients in chronic phase CML, there are good science-based recommendations for the treatment with imatinib. In the case of imatinib intolerance or resistance, the novel tyrosine kinase inhibitors dasatinib or nilotinib can be administered. The individual pre-treatment has to be respected for therapy decisions in advanced phases of CML. Patients should be advised to take part in clinical studies.
Key words
chronic myeloid leukaemia (CML) - chronic phase CML - advanced phase CML - treatment - imatinib intolerance - imatinib resistance
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Korrespondenz
PD Dr. Andreas Willer
Zentrum für Tumordiagnostik und - therapie Paracelsus-Klinik
Am Natruper Holz 69
49076 Osnabrück
Email: andreas.willer@pk-mx.de