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Dtsch Med Wochenschr 2007; 132(45): 2378-2382
DOI: 10.1055/s-2007-993084
DOI: 10.1055/s-2007-993084
Aktuelle Diagnostik & Therapie | Review article
Gastroenterologie, Heptatologie, Gynäkologie© Georg Thieme Verlag KG Stuttgart · New York
Intrahepatische Schwangerschaftscholestase: neue molekulare Mechanismen und klinische Behandlungspfade
Intrahepatic cholestasis of pregnancy: new molecular mechanisms and clinical pathwaysFurther Information
Publication History
eingereicht: 12.6.2007
akzeptiert: 9.8.2007
Publication Date:
31 October 2007 (online)

Schlüsselwörter
Schwangerschaftscholestase
Key words
cholestasis of pregnancy
Literatur
- 1
Bacq Y, Sapey T, Brechot M C, Pierre F. et al .
Intrahepatic cholestasis of pregnancy: a French prospective study.
Hepatology.
1997;
26
358-364
MissingFormLabel
- 2
Bacq Y.
Intrahepatic cholestasis of pregnancy.
Clin Liver Dis.
1999;
3
1-13
MissingFormLabel
- 3
Beuers U.
Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis.
Nat Clin Pract Gastroenterol Hepatol.
2006;
3
318-328
MissingFormLabel
- 4
Binder T, Salaj P, Zima T. et al .
Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine
in the treatment of intrahepatic cholestasis of pregnancy.
J Perinat Med.
2006;
34
383-391
MissingFormLabel
- 5
Brites D.
Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance
and improvement by ursodeoxycholic acid.
Ann Hepatol.
2002;
1
20-28
MissingFormLabel
- 6
Burrows R F, Clavisi O, Burrows E.
Interventions for treating cholestasis in pregnancy.
Cochrane Database Syst Rev.
2001;
CD000493
MissingFormLabel
- 7
Diac M, Kenyon A, Nelson-Piercy C. et al .
Dexamethasone in the treatment of obstetric cholestasis: a case series.
J Obstet Gynaecol.
2006;
26
110-114
MissingFormLabel
- 8
Dixon P H, Weerasekera N, Linton K J. et al .
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy:
evidence for a defect in protein trafficking.
Hum Mol Genet.
2000;
9
1209-1217
MissingFormLabel
- 9
Girling J C.
Obstetric cholestasis.
Royal College of Obstetricians and Gynaecologists Guidelines.
2006;
43
1-10
MissingFormLabel
- 10
Glantz A, Marschall H U, Lammert F, Mattsson L A.
Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone
and ursodeoxycholic acid.
Hepatology.
2005;
42
1399-1405
MissingFormLabel
- 11
Glantz A, Marschall H U, Mattsson L A.
Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and
fetal complication rates.
Hepatology.
2004;
40
467-474
MissingFormLabel
- 12
Hirvioja M L, Tuimala R, Vuori J.
The treatment of intrahepatic cholestasis of pregnancy by dexamethasone.
Br J Obstet Gynaecol.
1992;
99
109-111
MissingFormLabel
- 13
Jacquemin E, Cresteil D, Manouvrier S. et al .
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis
of pregnancy.
Lancet.
1999;
353
210-211
MissingFormLabel
- 14
Keitel V, Vogt C, Häussinger D, Kubitz R.
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis
of pregnancy.
Gastroenterology.
2006;
131
624-629
MissingFormLabel
- 15
Kenyon A P, Piercy C N, Girling J. et al .
Pruritus may precede abnormal liver function tests in pregnant women with obstetric
cholestasis: a longitudinal analysis.
Br J Obstet Gynaecol.
2001;
108
1190-1192
MissingFormLabel
- 16
Kondrackiene J, Beuers U, Kupcinskas L.
Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic
cholestasis of pregnancy.
Gastroenterology.
2005;
129
894-901
MissingFormLabel
- 17
Lammert F, Marschall H U, Glantz A, Matern S.
Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management.
J Hepatol.
2000;
33
1012-1021
MissingFormLabel
- 18
Lammert F, Marschall H U, Matern S.
Intrahepatic cholestasis of pregnancy.
Curr Treat Options Gastroenterol.
2003;
6
123-132
MissingFormLabel
- 19 Lammert F, Rath W. Lebererkrankungen. München, Jena: Urban & Fischer In: Kainer F, Hrsg. Facharzt Geburtsmedizin 2006: 523-554
MissingFormLabel
- 20
Muehlenberg K, Wiedmann K H, Keppeler H. et al .
Rezidivierende Schwangerschaftscholestase und perlenschnurartige Choledocholithiasis
bei einer Patientin mit Stoppcodon im ABCB4-Gen des hepatischen Phospholipid-Transporters.
Z Gastroenterol.
2007;
im Druck
MissingFormLabel
- 21
Mullenbach R, Bennett A, Tetlow N. et al .
ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.
Gut.
2005;
54
829-834
MissingFormLabel
- 22
Painter J N, Savander M, Ropponen A. et al .
Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy.
Eur J Hum Genet.
2005;
13
435-439
MissingFormLabel
- 23
Palma J, Reyes H, Ribalta J. et al .
Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind
study controlled with placebo.
J Hepatol.
1997;
27
1022-1028
MissingFormLabel
- 24
Paus T C, Schneider G, van de Vondel P. et al .
Diagnosis and therapy of intrahepatic cholestasis of pregnancy.
Z Gastroenterol.
2004;
42
623-628
MissingFormLabel
- 25
Reyes H, Baez M E, Gonzalez M C. et al .
Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy,
in normal pregnancies and in healthy individuals, in Chile.
J Hepatol.
2000;
32
542-549
MissingFormLabel
- 26
Reyes H, Sjövall J.
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Ann Med.
2000;
32
94-106
MissingFormLabel
- 27
Ropponen A, Sund R, Riikonen S. et al .
Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases:
a population-based study.
Hepatology.
2006;
43
723-728
MissingFormLabel
- 28
Schneider G, Paus T C, Kullak-Ublick G A. et al .
Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic
cholestasis of pregnancy.
Hepatology.
2007;
45
150-158
MissingFormLabel
- 29
Wasmuth H E, Glantz A, Keppeler H. et al .
Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants
of the hepatobiliary phospholipid transporter ABCB4 gene.
Gut.
2007;
56
265-270
MissingFormLabel
- 30
Williamson C, Gorelik J, Eaton B M. et al .
The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism
for intra-uterine fetal death in obstetric cholestasis.
Clin Sci.
2001;
100
363-369
MissingFormLabel
- 31
Williamson C, Hems L M, Goulis D G. et al .
Clinical outcome in a series of cases of obstetric cholestasis identified via a patient
support group.
Br J Obstet Gynaecol.
2004;
111
676-681
MissingFormLabel
Prof. Dr. med. Frank Lammert
Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn
Sigmund-Freud-Straße 25
53127 Bonn
Phone: 0228/287/11249
Fax: 0228/287/14698
Email: frank.lammert@ukb.uni-bonn.de