“Computational Neuropsychiatry” of Working Memory Disorders in Schizophrenia: The Network Connectivity in Prefrontal Cortex - Data and Models

Abstract

The use of mathematical and computer-assisted modeling of brain mechanisms involved in mental disorders can be called “Computational Neuropsychiatry”. It was already demonstrated by several initiatives that computational modeling is an important contribution to understand neuronal circuits that could generate mental functions and dysfunctions. However, this attempt needs close collaboration between experimental neurobiologists, clinical psychiatry and systems science. In order to do so, we have organized a series of workshops on computational neuropsychiatry. Here we try to give basic information on data and modeling of the prefrontal cortical neurocircuitry that is involved in working memory and its disorders in schizophrenia. Special emphasis is devoted to the basic features of computational modeling.

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