Steroidal Alkaloids from Veratrum japonicum with Genotoxicity on Brain Cell DNA of the Cerebellum and Cerebral Cortex in Mice

Abstract

A new steroidal alkaloid (1), together with three known steroidal alkaloids (2 - 4), has been isolated from the roots and rhizomes of Veratrum japonicum (Baker) Loes. f.., their structures were established as neogermine (1), germine (2), germerine (3), and neogermbudine (4) by means of physicochemical properties and spectroscopic analysis. Compounds 1 - 4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay).

Liliaceae - Veratrum japonicum (Baker) Loes. f. - neogermine - genotoxicity

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