Neonatal Middle Cerebral Artery Infarction: Association with Elevated Maternal Anticardiolipin Antibodies

Leyla F. Akanli; Sunil S. Trasi; Kalpna Thuraisamy; Marcia P. Bergtraum; Annabella Thantu; Rita F. Fischer; Nicole Cohen-Addad

doi:10.1055/s-2007-993965

American Journal of Perinatology, Table of Contents

Am J Perinatol 1998; 15(6): 399-402
DOI: 10.1055/s-2007-993965

ORIGINAL ARTICLE

Neonatal Middle Cerebral Artery Infarction: Association with Elevated Maternal Anticardiolipin Antibodies

Leyla F. Akanli¹ , Sunil S. Trasi² , Kalpna Thuraisamy³ , Marcia P. Bergtraum⁴ , Annabella Thantu⁵ , Rita F. Fischer⁶ , Nicole Cohen-Addad⁶

¹Department of Pediatrics, Division of Pulmonology, Westchester County Medical Center, Valhalla, New York, Medical College, Valhalla, New York
²Department of Radiology, Section of Neuroradiology, Saint Vincents Hospital and Medical Center, New York, NY, New York Medical College, Valhalla, New York
³Department of Medicine and Pediatrics, Saint Vincents Hospital and Medical Center, New York, NY
⁴Department of Pediatrics, Schneider's Children's Hospital, Long Island, New York
⁵Department of Pediatrics, Kenmore Mercy Hospital, Kenmore, New York, State University of New York, Buffalo, New York
⁶Department of Pediatrics, Division of Neonatology, Saint Vincents Hospital and Medical Center, New York, NY, New York Medical College, Valhalla, New York

Abstract

ABSTRACT

A full-term neonate was born to a 41-year-old woman via elective primary cesarean section for frank breech presentation after a 41-week pregnancy. Starting at 6 hr of age the infant presented with multiple episodes of apnea and cyanosis, in association with moderate hypotonia, subsequently requiring assisted ventilatory support for 2 days. Computerized axial tomography of the brain revealed infarction in the distribution of the left middle cerebral artery. Magnetic resonance imaging of the brain showed a left middle cerebral artery territory infarct and also a small right posterior-temporal in-farct. Magnetic resonance angiography of the head and neck was normal, however, inferring that the vascular infarction was peripheral in location. Maternal anticardiolipin antibodies were elevated. This is only the fifth reported case of cerebral infarction in a newborn in association with elevated maternal anticardiolipin antibodies.

Keywords

Newborn - cerebral infarct - anticardiolipin antibodies

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