Coagulation and Fibrinolysis Parameters in Normal Pregnancy and in Gestational Diabetes

Jordi Bellart; Rosa Gilabert; Jordi Fontcuberta; Elena Carreras; Ramón M. Miralles; Lluis Cabero

doi:10.1055/s-2007-994069

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 1998; 15(8): 479-486
DOI: 10.1055/s-2007-994069

ORIGINAL ARTICLE

Coagulation and Fibrinolysis Parameters in Normal Pregnancy and in Gestational Diabetes

Jordi Bellart¹ , Rosa Gilabert² , Jordi Fontcuberta³ , Elena Carreras⁴ , Ramón M. Miralles¹ , Lluis Cabero¹ ^, ⁴

¹Servei d'Obstetrícia i Ginecologia, Unitat de Medicina Materno-fetal, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona
²Unitat d'Anatomia Humana i Embriologia, Departament Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Tarragona
³Servei d'Hematologia, Hospital Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona
⁴Servei d'Obstetrícia i Ginecologia, Hospital Materno-Infantil Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona

Abstract

ABSTRACT

The changes in coagulation and fibrinolysis parameters during pregnancy, delivery and 3 days after delivery were evaluated in normotensive and gestational diabetes pregnant women. Normal pregnant women (n = 60) and pregnant women with gestational diabetes (n = 15) formed the study population. Coagulation and fibrinolysis parameters were estimated using commercial tests. Antithrombin III, thrombin-antithrombin III complexes, heparin cofactor II, protein C, protein S, tissue plasminogen activator, (t-PA) D-dimer and plasminogen activator inhibitor (PAI-1 and PAI-2) activities in normal and gestational diabetes pregnancies were determined. Thrombin-antithrombin III complexes increased and coagulation inhibitors decreased in gestational diabetes. Plasminogen activator inhibitors remained unchanged and t-PA levels increased in gestational diabetes.

Keywords

Coagulation - fibrinolysis - pregnancy - diabetes

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