Am J Perinatol 1997; 14(3): 135-138
DOI: 10.1055/s-2007-994113
ORIGINAL ARTICLE

© 1997 by Thieme Medical Publishers, Inc.

Pregnancies in a Patient with Congenital Absence of Prothrombin Activity: Case Report

Val A. Catanzarite1 , William F. Novotny2 , Larry M. Cousins1 , Jack M. Schneider1
  • 1Maternal-Fetal Medicine, Mary Birch Hospital for Women at Sharp Memorial, San Diego, California
  • 2Genentech, Inc., San Francisco, California
Further Information

Publication History

Publication Date:
04 March 2008 (online)

ABSTRACT

Congenital hypoprothrombinemias are very rare, inherited disorders in which factor II (prothrombin) levels and/or activity are extremely low or absent. We report eight pregnancies in a patient with this disorder. Obstetric complications attributed to the coagulation disturbance included first-trimester bleeding in each pregnancy, miscarriage in four of the pregnancies, spontaneous maternal subarachnoid hemorrhage in one, and postpartum hemorrhage in one of four term pregnancies despite administration of clotting factor concentrate. The management of pregnancy in congenital hypoprothrombinemia, and issues of coagulation factor replacement, are discussed.