Plasma Thrombomodulin Levels in Women with Systemic Lupus Erythematosus

Chaur-Dong Hsu; Daniel W. Chan; Brian Iriye; Timoth R. B. Johnson; Shih-Fen Hong; Michelle Petri

doi:10.1055/s-2007-994394

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 1995; 12(1): 27-29
DOI: 10.1055/s-2007-994394

ORIGINAL ARTICLE

Plasma Thrombomodulin Levels in Women with Systemic Lupus Erythematosus

Chaur-Dong Hsu, Daniel W. Chan, Brian Iriye, Timoth R.B. Johnson, Shih-Fen Hong, Michelle Petri

Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics (C.-D.H, B.I., T.R.B.J., S-F.H.), Division of Clinical Chemistry, Department of Pathology (D.W.C.), Division of Rheumatology, Department of Medicine (M.P.), Johns Hopkins University School of Medicine, Baltimore, Maryland, and Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, Yale University School of Medicine, New Haven, Connecticut (C.-D.H.)

Abstract

ABSTRACT

Thrombomodulin (TM), an endothelial cell membrane glycoprotein, is released into blood as a soluble TM antigen after inflammation or injury to endothelium. Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation of vascular endothelium. The objective of this study is to determine the circulating TM levels in pregnant and nonpregnant SLE women and the correlation of plasma TM levels with variables used to assess SLE activity. We found that there were no significant differences in plasma TM levels among pregnant SLE, nonpregnant SLE, and normal pregnant patients. However, significantly higher plasma TM levels were found in some SLE women with active disease or preeclampsia.

Keywords

Thrombomodulin - systemic lupus erythematosus - endothelial damage

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