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Am J Perinatol 1994; 11(2): 91-93
DOI: 10.1055/s-2007-994563
ORIGINAL ARTICLE

© 1994 by Thieme Medical Publishers, Inc.

Neonatal Adrenergic Blockade Following Single dose Maternal Labetalol Administration

Judith M. Klarr, Varsha Bhatt-Mehta, Steven M. Donn
  • Department of Pediatrics, Section of Newborn Services and Pharmacy Services (V.B.-M.), University of Michigan Medical Center, Ann Arbor, Michigan
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Publication Date:
04 March 2008 (online)

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ABSTRACT

A single 30 mg intravenous dose of labetalol given 20 minutes prior to cesarean delivery at 35 weeks of gestation for severe pregnancy-induced hypertension was associated with symptoms of β-adrenergic blockade (hypoglycemia, bradycardia, hypotension) in preterm twins. The infants were subsequently found to have therapeutic labetalol concentrations (180 and 150 ng/mL) in umbilical cord blood. The pharmacology of transplacental labetalol is reviewed and potential mechanisms for neonatal β-adrenergic blockade are discussed.