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Am J Perinatol 1993; 10(4): 327-329
DOI: 10.1055/s-2007-994753
ORIGINAL ARTICLE

© 1993 by Thieme Medical Publishers, Inc.

Combined Pentalogy of Cantrell and Sirenomelia: A Case Report with Speculation about a Common Etiology

James F.X. Egan, Boris M. Petrikovsky, Anthony M. Vintzileos, John F. Rodis, Winston M. Campbell
  • University of Connecticut Health Center, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Farmington, Connecticut
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Publication Date:
04 March 2008 (online)

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ABSTRACT

A case of combined pentalogy of Cantrell with sirenomelia in a monozygotictwin is described. Similar cases from the world literature are reviewed. Current concepts on the etiology of anterior midline ventral wall defects and sirenomelia are detailed. It has been proposed that anterior midline ventral wall defects may be caused by either monozygotic twinning or vascular dysplasia. Likewise, a vascular steal phenomenon causes sirenomelia. A common etiology for these defects, an alteration in vascular development, is proposed.