Acute Maternal Renal Insufficiency in Premature Labor Treated with Indomethacin

Ralph M. Steiger; Eve L. Boyd; David R. Powers; Michael P. Nageotte; Craig V. Towers

doi:10.1055/s-2007-994767

American Journal of Perinatology, Table of Contents

Am J Perinatol 1993; 10(5): 381-383
DOI: 10.1055/s-2007-994767

ORIGINAL ARTICLE

Acute Maternal Renal Insufficiency in Premature Labor Treated with Indomethacin

Ralph M. Steiger, Eve L. Boyd, David R. Powers, Michael P. Nageotte, Craig V. Towers

University of California Irvine Medical Center, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, and Department of Internal Medicine, Division of Nephrology, Orange, California, and Long Beach Memorial Medical Center, Long Beach, California

Abstract

ABSTRACT

Three cases of acute renal insufficiency in pregnant women who were treated with indomethacin for premature labor are reported. At the time of presentation, all three women had normal renal function but within 30 hours of indomethacin therapy they were noted to have significant decreases in urine output and rising serum creatinines. The average time to recovery of renal function was 5 days. A consistent feature in all three women was the development of dyspnea associated with hypoxemia.

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