Pregnancy-Induced Hypertension and Early Neonatal Death: A Case-Control Study

Jun Zhang; Wen-wei Cai; David J. Lee

doi:10.1055/s-2007-994772

American Journal of Perinatology, Table of Contents

Am J Perinatol 1993; 10(5): 401-403
DOI: 10.1055/s-2007-994772

ORIGINAL ARTICLE

Pregnancy-Induced Hypertension and Early Neonatal Death: A Case-Control Study

Jun Zhang¹ , Wen-wei Cai² , David J. Lee³

¹Carolina Population Center and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;
²Department of Maternal and Child Health, Shanghai Medical University, Shanghai, China;
³Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, Florida

Abstract

ABSTRACT

Literature on the association between pregnancy-induced hypertension and early neonatal death is limited. The present case-control study consisted of 342 early neonatal deaths and 523 frequency-matched controls. After controlling for other factors such as infant sex, gravidity, maternal age, threatened abortion, and maternal anemia, moderate to severe pregnancy-induced hypertension was associated with an increased risk of early neonatal death with apparent dose-effect gradients (odds ratio = 1.8 for moderate and 2.2 for severe). The biologic plausibility of pregnancy-induced hypertension as a cause of neonatal mortality is discussed.

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