Zidovudine Pharmacokinetics During Pregnancy

Rhoda S. Sperling; John Roboz; Renata Dische; Demetra Silides; Ian Holzman; Edward Jew

doi:10.1055/s-2007-994781

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 1992; 9(4): 247-249
DOI: 10.1055/s-2007-994781

ORIGINAL ARTICLE

Zidovudine Pharmacokinetics During Pregnancy

Rhoda S. Sperling, John Roboz, Renata Dische, Demetra Silides, Ian Holzman, Edward Jew

Departments of Obstetrics, Gynecology and Reproductive Science, Neoplastic Diseases, Pathology, and Pediatrics, The Mount Sinai School of Medicine, New York, New York

Abstract

ABSTRACT

As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.

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