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DOI: 10.1055/s-2007-995393
© Georg Thieme Verlag KG Stuttgart · New York
Microcarcinoid tumor diagnosed with high-resolution magnification endoscopy and narrow band imaging
Publication History
Publication Date:
18 February 2008 (online)
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A 63-year-old patient presented with persistent dyspepsia. Endoscopy revealed an 8-mm nodule on the anterior wall of the greater curvature in the proximal part of the body of the stomach. Histological analysis demonstrated a well-differentiated tumor showing positive immunostaining with chromogranin with a background mucosa showing features of atrophic gastritis. Gastric pH and fasting serum gastrin levels were elevated. A diagnosis of a type I carcinoid tumor was made. The patient then underwent endoscopic mucosal resection with complete resection of the lesion. Follow-up endoscopy 3 months later showed a scar at the previous resection site. However, a diminutive, flat, reddened lesion measuring less than 3 mm with the appearance of an erosion was detected at a separate site on the posterior wall of the greater curvature ([Fig. 1] a). Narrow-band imaging demonstrated that, at the center of the lesion, the pit structure had disappeared ([Fig. 1] b). Magnification endoscopy with white light revealed that the subepithelial capillary network was well preserved, but underneath the epithelium, a faint yellowish hue could be seen ([Fig. 1] c). These findings were distinctly different from those of a gastric erosion or a minute gastric carcinoma. In an erosion dilated subepithelial capillaries are seen, and in the center of the erosion whitish inflammatory exudates will be visualized [1]. On the other hand, a flat early carcinoma would exhibit proliferation of the subepithelial capillaries, which would be irregular in both caliber and tortuosity [2]. Taking into consideration the patient’s previous history, we suspected the lesion could have originated from an endocrine nest/microcarcinoid [3] which had grown just beneath the epithelium. The histopathological analysis of the lesion revealed a minute carcinoid tumor ([Fig. 1] d). This case illustrates the differential diagnosis between three lesions which appear very similar: an erosion, a flat early carcinoma, and a minute carcinoid, and shows the utility of high-resolution magnification endoscopy with narrow-band imaging in differentiating them.
Fig. 1 a A diminutive, flat, reddened lesion measuring less than 3 mm with the appearance of an erosion at the posterior wall of the greater curvature of the stomach. b Narrow-band imaging demonstrated that at the center of the lesion, the pit structure had disappeared. c High-resolution magnification endoscopy revealed that the subepithelial capillary network was well preserved, but underneath the epithelium a faint yellowish hue could be seen. d Endocrine nest/microcarcinoid which had grown just beneath the epithelium.
Endoscopy_UCTN_Code_CCL_1AB_2AD_3AB
References
- 1 Yao K, Iwashita A, Kikuchi Y. et al . Novel zoom endoscopy technique for visualizing the microvascular architecture in gastric mucosa [review]. Clin Gastroenterol Hepatol. 2005; 3 (7 Suppl 1) S23-26
- 2 Yao K, Iwashita A, Tanabe H. et al . Novel zoom endoscopy technique for diagnosis of small flat gastric cancer: a prospective, blind study. Clin Gastroenterol Hepatol. 2007; 5 869-78
- 3 Nojiri T, Ikegami M. Multiple minute carcinoids in type A gastritis: attempt at 3-D reconstruction. Pathol Int. 2001; 51 504-510
R. Singh, MRCP
Wolfson Digestive Diseases Centre
University Hospital
Queen’s Medical Centre
Nottingham
NG7 2UH
United Kingdom
Fax: +44-115-9249924
Email: rajvindersingh2003@yahoo.com