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Laryngorhinootologie 2008; 87: S32-S53
DOI: 10.1055/s-2007-995537
Früherkennung

© Georg Thieme Verlag KG Stuttgart · New York

Früherkennung allergischer Erkrankungen

L.  Klimek1
  • 1Zentrum für Rhinologie und Allergologie, Wiesbaden
Further Information

Publication History

Publication Date:
28 March 2008 (online)

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Zusammenfassung

Asthmatische Beschwerden existieren seit der Antike, der „Heuschnupfen” wurde Ende des 18. Jahrhunderts erstmals beschrieben. Heute, knapp 100 Jahre nach der Einführung des Begriffs der Allergie, sind allergische Erkrankungen zur Volkskrankheit geworden, die in der westlichen Welt ein Drittel der Bevölkerung betreffen. Diese Erkrankungen gehören heute zu den häufigsten chronischen Erkrankungen, machen einen beträchtlichen Teil der gesamten Gesundheitskosten aus und sind von großer gesundheitspolitischer Relevanz.Bedingt durch genetische sowie Umweltfaktoren ist die Bandbreite an IgE-vermittelten allergischen Erkrankungen recht groß; zu ihnen gehören z. B. die atopische Dermatitis, das Asthma bronchiale oder die Rhinitis allergika. In dieser Übersichtsarbeit soll - aufgrund des Schwerpunkts im HNO-Bereich - die allergische Rhinitis im Mittelpunkt der Überlegungen zur Früherkennung allergischer Erkrankungen stehen.

Schlüsselwörter

Rhinitis allergika - atopische/allergische Erkrankungen - In-vitro-Diagnostik - Spezifische Immuntherapie

Literatur

  • 1 Bousquet J, Van CP, Khaltaev N. Allergic rhinitis and its impact on asthma.  J Allergy Clin Immunol. 2001;  108 S147-S334
    CrossrefPubMedSearch in Google Scholar
  • 2 Pariente P D, LePen C, Los F, Bousquet J. Quality-of-life outcomes and the use of antihistamines in a French national population-based sample of patients with perennial rhinitis.  Pharmacoeconomics. 1997;  12 585-595
    CrossrefPubMedSearch in Google Scholar
  • 3 Ring J, Wenning J. Weißbuch: Allergie in Deutschland 2000. Deutsche Gesellschaft für Allergie und klinische Immunologie. München; Urban und Vogel 2000
    Search in Google Scholar
  • 4 Statistisches Bundesamt .Gesundheitsbericht für Deutschland. Spezialbericht Allergien. Stuttgart; Metzler-Poeschel 2000
    Search in Google Scholar
  • 5 Klimek L, Reichenbach M, Mewes T, Mann W. Untersuchungen zur Reproduzierbarkeit und jahreszeitlichen Abhängigkeit von spezifischen intranasalen Provokationstests bei Birkenpollenallergikern.  Laryngorhinootologie. 1997;  76 475-479
    PubMedSearch in Google Scholar
  • 6 Connell J T. Quantitative intranasal pollen challenges. 3. The priming effect in allergic rhinitis.  J Allergy. 1969;  43 33-44
    PubMedSearch in Google Scholar
  • 7 Ciprandi G, Buscaglia S, Pesce G, Pronzato C, Ricca V, Parmiani S, Bagnasco M, Canonica G W. Minimal persistent inflammation is present at mucosal level in patients with asymptomatic rhinitis and mite allergy.  J Allergy Clin Immunol. 1995;  96 971-979
    CrossrefPubMedSearch in Google Scholar
  • 8 Kripke M L, Munn C G, Jeevan A, Tang J M, Bucana C. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.  J Immunol. 1990;  145 2833-2838
    PubMedSearch in Google Scholar
  • 9 Picker L J. Control of lymphocyte homing.  Curr Opin Immunol. 1994;  6 394-406
    CrossrefPubMedSearch in Google Scholar
  • 10 Johnson J G, Jenkins M K. Co-stimulatory functions of antigen-presenting cells.  J Invest Dermatol. 1992;  99 62S-65S
    CrossrefPubMedSearch in Google Scholar
  • 11 Mosmann T R, Cherwinski H, Bond M W, Giedlin M A, Coffman R L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986.  J Immunol. 2005;  175 5-14
    PubMedSearch in Google Scholar
  • 12 Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni M P, Rugiu F S, Carti M, Ricci M, Romagnani S. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.  J Immunol. 1992;  148 2142-2147
    PubMedSearch in Google Scholar
  • 13 Modlin R L. Th1-Th2 paradigm: insights from leprosy.  J Invest Dermatol. 1994;  102 828-832
    CrossrefPubMedSearch in Google Scholar
  • 14 Jones H E, Inouye J C, McGerity J L, Lewis C W. Atopic disease and serum immunoglobulin-E.  Br J Dermatol. 1975;  92 17-25
    PubMedSearch in Google Scholar
  • 15 Enk A H, Katz S I. Identification and induction of keratinocyte-derived IL-10.  J Immunol. 1992;  149 92-95
    PubMedSearch in Google Scholar
  • 16 Vercelli D. Regulation of IgE synthesis.  Allergy Proc. 1993;  14 413-416
    CrossrefPubMedSearch in Google Scholar
  • 17 van Reijsen F C, Bruijnzeel-Koomen C A, Kalthoff F S, Maggi E, Romagnani S, Westland J K, Mudde G C. Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis.  J Allergy Clin Immunol. 1992;  90 184-193
    CrossrefPubMedSearch in Google Scholar
  • 18 Kay A B, Ying S, Varney V, Gaga M, Durham S R, Moqbel R, Wardlaw A J, Hamid Q. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.  J Exp Med. 1991;  173 775-778
    CrossrefPubMedSearch in Google Scholar
  • 19 Schartz L, Huff T. Biology of mast cells and Basophils. In: Middleton EJ, Reed CE, Ellis EF (eds) Allergy, Principles and Practice. St. Louis; Mosby-Year-Book 1993
    Search in Google Scholar
  • 20 Church M K, el-Lati S, Caulfield J P. Neuropeptide-induced secretion from human skin mast cells.  Int Arch Allergy Appl Immunol. 1991;  94 310-318
    PubMedSearch in Google Scholar
  • 21 Wardlaw A J, Moqbel R, Cromwell O, Kay A B. Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils.  J Clin Invest. 1986;  78 1701-1706
    CrossrefPubMedSearch in Google Scholar
  • 22 Wang J M, Rambaldi A, Biondi A, Chen Z G, Sanderson C J, Mantovani A. Recombinant human interleukin 5 is a selective eosinophil chemoattractant.  Eur J Immunol. 1989;  19 701-705
    CrossrefPubMedSearch in Google Scholar
  • 23 Schleimer R P, Sterbinsky S A, Kaiser J, Bickel C A, Klunk D A, Tomioka K, Newman W, Luscinskas F W, Gimbrone Jr M A, McIntyre B W. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.  J Immunol. 1992;  148 1086-1092
    PubMedSearch in Google Scholar
  • 24 Skoner D P. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis.  J Allergy Clin Immunol. 2001;  108 S2-S8
    CrossrefPubMedSearch in Google Scholar
  • 25 Craig T J, Teets S, Lehman E B, Chinchilli V M, Zwillich C. Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids.  J Allergy Clin Immunol. 1998;  101 633-637
    CrossrefPubMedSearch in Google Scholar
  • 26 Vuurman E F, vanVeggel L M, Uiterwijk M M, Leutner D, O’Hanlon J F. Seasonal allergic rhinitis and antihistamine effects on children’s learning.  Ann Allergy. 1993;  71 121-126
    PubMedSearch in Google Scholar
  • 27 Lack G. Pediatric allergic rhinitis and comorbid disorders.  J Allergy Clin Immunol. 2001;  108 S9-S15
    CrossrefPubMedSearch in Google Scholar
  • 28 Wright A L, Holberg C J, Martinez F D, Halonen M, Morgan W, Taussig L M. Epidemiology of physician-diagnosed allergic rhinitis in childhood.  Pediatrics. 1994;  94 895-901
    PubMedSearch in Google Scholar
  • 29 Leynaert B, Bousquet J, Neukirch C, Liard R, Neukirch F. Perennial rhinitis: An independent risk factor for asthma in nonatopic subjects: results from the European Community Respiratory Health Survey.  J Allergy Clin Immunol. 1999;  104 301-304
    CrossrefPubMedSearch in Google Scholar
  • 30 Ruoppi P, Seppa J, Nuutinen J. Acute frontal sinusitis: etiological factors and treatment outcome.  Acta Otolaryngol. 1993;  113 201-205
    CrossrefPubMedSearch in Google Scholar
  • 31 Keith P K, Conway M, Evans S, Wong D A, Jordana G, Pengelly D, Dolovich J. Nasal polyps: effects of seasonal allergen exposure.  J Allergy Clin Immunol. 1994;  93 567-574
    CrossrefPubMedSearch in Google Scholar
  • 32 Bachert C, Hormann K, Mosges R, Rasp G, Riechelmann H, Muller R, Luckhaupt H, Stuck B A, Rudack C. An update on the diagnosis and treatment of sinusitis and nasal polyposis.  Allergy. 2003;  58 176-191
    CrossrefPubMedSearch in Google Scholar
  • 33 Corey J P, Adham R E, Abbass A H, Seligman I. The role of IgE-mediated hypersensitivity in otitis media with effusion.  Am J Otolaryngol. 1994;  15 138-144
    PubMedSearch in Google Scholar
  • 34 McColley S A, Carroll J L, Curtis S, Loughlin G M, Sampson H A. High prevalence of allergic sensitization in children with habitual snoring and obstructive sleep apnea.  Chest. 1997;  111 170-173
    CrossrefPubMedSearch in Google Scholar
  • 35 Mutius E, Martinez F D, Fritzsch C, Nicolai T, Roell G, Thiemann H H. Prevalence of asthma and atopy in two areas of West and East Germany.  Am J Respir Crit Care Med. 1994;  149 358-364
    PubMedSearch in Google Scholar
  • 36 Mutius E. Epidemiologie des Asthma bronchiale im Kindesalter.  Pneumologie. 1997;  51 949-961
    PubMedSearch in Google Scholar
  • 37 Martinez F D, Wright A L, Taussig L M, Holberg C J, Halonen M, Morgan W J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates.  N Engl J Med. 1995;  332 133-138
    CrossrefPubMedSearch in Google Scholar
  • 38 Martinez F D. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective?.  Thorax. 1994;  49 1189-1191
    PubMedSearch in Google Scholar
  • 39 Silverman M. Childhood asthma and other weezing disorders. Chapman & Hall Medical 1995
    Search in Google Scholar
  • 40 Mutius E. Air pollution and asthma. Immunotherapy in Asthma. Marcel Dekker Ltd 1995
    Search in Google Scholar
  • 41 . Health effects of atmospheric acids and their precursors. Report of the ATS workshop on the Health Effects of Atmospheric Acids and their Precursors.  Am Rev Respir Dis. 1991;  144 464-467
    PubMedSearch in Google Scholar
  • 42 Committee Of The Environmental And Occupational Health Assembly Of The American Thoracic Society (ATS) . Health effects of outdoor air pollution, Part 1.  Am J Respir Crit Care Med. 1996;  153 3-50
    PubMedSearch in Google Scholar
  • 43 Delacourt C, Labbe D, Vassault A, Brunet-Langot D, de Blic J, Scheinmann P. Sensitization to inhalant allergens in wheezing infants is predictive of the development of infantile asthma.  Allergy. 1994;  49 843-847
    CrossrefPubMedSearch in Google Scholar
  • 44 Hosoi J, Murphy G F, Egan C L, Lerner E A, Grabbe S, Asahina A, Granstein R D. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide.  Nature. 1993;  363 159-163
    PubMedSearch in Google Scholar
  • 45 Wiesner-Menzel L, Schulz B, Vakilzadeh F, Czarnetzki B M. Electron microscopical evidence for a direct contact between nerve fibres and mast cells.  Acta Derm Venereol. 1981;  61 465-469
    PubMedSearch in Google Scholar
  • 46 Stingl G, Katz S I, Clement L, Green I, Shevach E M. Immunologic functions of Ia-bearing epidermal Langerhans cells.  J Immunol. 1978;  121 2005-2013
    PubMedSearch in Google Scholar
  • 47 Inaba K, Schuler G, Witmer M D, Valinksy J, Atassi B, Steinman R M. Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes.  J Exp Med. 1986;  164 605-613
    CrossrefPubMedSearch in Google Scholar
  • 48 Robertson I, Greaves M W. Responses of human skin blood vessels to synthetic histamine analogues.  Br J Clin Pharmacol. 1978;  5 319-322
    PubMedSearch in Google Scholar
  • 49 Smith J S, Mansfield L E, de Shazo R, Nelson H S. An evaluation of the pharmacologic inhibition of the immediate and late cutaneous effect to allergen.  J Allergy Clin Immunol. 1980;  65 188
    PubMedSearch in Google Scholar
  • 50 Rietschel R L, Fowler Jr J F. Fisher’s Contact Dermatitis. Baltimore; Williams and Wilkin 1995
    Search in Google Scholar
  • 51 Lockey R F, Benedict L M, Turkeltaub P C, Bukantz S C. Fatalities from immunotherapy (IT) and skin testing (ST).  J Allergy Clin Immunol. 1987;  79 660-677
    CrossrefPubMedSearch in Google Scholar
  • 52 American Academy of Allergy and Immunology . The waiting period after allergen skin testing and immunotherapy.  J Allergy Clin Immunol. 1990;  85 526-527
    CrossrefPubMedSearch in Google Scholar
  • 53 Pepys J. Skin testing.  Br J Hosp Med. 1975;  14 412
    PubMedSearch in Google Scholar
  • 54 Brown H M, Su S, Thantrey N. Prick testing for allergens standardized by using a precision needle.  Clin Allergy. 1981;  11 95-98
    PubMedSearch in Google Scholar
  • 55 Osterballe O, Weeke B. A new lancet for skin prick testing.  Allergy. 1979;  34 209-212
    CrossrefPubMedSearch in Google Scholar
  • 56 Dreborg S. Food allergy in pollen-sensitive patients.  Ann Allergy. 1988;  61 41-46
    PubMedSearch in Google Scholar
  • 57 Dreborg S, Backman A, Basomba A. Skin tests used in type I allergy testing. Position paper of the European Academy of Allergy and Clinical Immunology.  Allergy. 1989;  44 1
    CrossrefPubMedSearch in Google Scholar
  • 58 Mantoux C. Intradermoréaction de la tuberculose.  Cr Acad Sci. 1908;  147 355
    PubMedSearch in Google Scholar
  • 59 Chipps B E, Talamo R C, Mellits E D, Valentine M D. Immediate (IgE-mediated) skin testing in the diagnosis of allergic disease.  Ann Allergy. 1978;  41 211-215
    PubMedSearch in Google Scholar
  • 60 Voorhorst R. Perfection of skin testing technique. A review.  Allergy. 1980;  35 247-250
    CrossrefPubMedSearch in Google Scholar
  • 61 Aas K, Belin L. Suggestions for biologic qualitative testing and standardization of allergen extracts.  Acta Allergol. 1974;  29 238
    PubMedSearch in Google Scholar
  • 62 Skassa-Brociek W, Manderscheid J C, Michel F B, Bousquet J. Skin test reactivity to histamine from infancy to old age.  J Allergy Clin Immunol. 1987;  80 711-716
    CrossrefPubMedSearch in Google Scholar
  • 63 Bernstein I L. Proceeding of the task force of guidelines for standardizing old and new technologies used for the diagnosis and treatment of allergic diseases.  J Allergy Clin Immunol. 1988;  82 487
    CrossrefPubMedSearch in Google Scholar
  • 64 Bousquet J. In vivo methods for study of allergy: skin tests. In: Middleton EJ, Reed CE, Ellis EF (eds) Allergy, Principles and Practice. St. Louis; Mosby-Year-Book 1988
    Search in Google Scholar
  • 65 Lindblad J H, Farr R S. The incidence of positive intradermal reactions and the demonstration of skin sensitizing antibody to extracts of ragweed and dust in humans without history of rhinitis or asthma.  J Allergy. 1961;  32 392-401
    CrossrefPubMedSearch in Google Scholar
  • 66 Hagy G W, Settipane G A. Risk factors for developing asthma and allergic rhinitis. A 7-year follow-up study of college students.  J Allergy Clin Immunol. 1976;  58 330-336
    CrossrefPubMedSearch in Google Scholar
  • 67 Holgate A T, Church M K. Allergy. London, New York; Gower Medical Publishing 1993
    Search in Google Scholar
  • 68 Leynadier F, Sansarricq M, Didier J M, Dry J. Prick tests in the diagnosis of anaphylaxis to general anaesthetics.  Br J Anaesth. 1987;  59 683-689
    CrossrefPubMedSearch in Google Scholar
  • 69 . Workshop on experimental methodology for clinical studies of adverse reactions to foods and food additives.  J Allergy Clin Immunol. 1990;  86 421-442
    CrossrefPubMedSearch in Google Scholar
  • 70 Sutton B J, Gould H J. The human IgE network.  Nature. 1993;  366 421-428
    CrossrefPubMedSearch in Google Scholar
  • 71 Kulig M, Tacke U, Forster J, Edenharter G, Bergmann R, Lau S, Wahn V, Zepp F, Wahn U. Serum IgE levels during the first 6 years of life.  J Pediatr. 1999;  134 453-458
    PubMedSearch in Google Scholar
  • 72 Holford-Strevens V, Warren P, Wong C, Manfreda J. Serum total immunoglobulin E levels in Canadian adults.  J Allergy Clin Immunol. 1984;  73 516-522
    CrossrefPubMedSearch in Google Scholar
  • 73 Sitzmann F. Normalwerte. München; Hans Marseille Verlag 1986
    Search in Google Scholar
  • 74 Mensing H. Zur Differenzialdiagnose der Dermatitis atopica.  Allergologie. 1994;  17 477-480
    PubMedSearch in Google Scholar
  • 75 Rothenberg M E. Eosinophilia.  N Engl J Med. 1998;  338 1592-1600
    CrossrefPubMedSearch in Google Scholar
  • 76 Burney P, Malmberg E, Chinn S, Jarvis D, Luczynska C, Lai E. The distribution of total and specific serum IgE in the European Community Respiratory Health Survey.  J Allergy Clin Immunol. 1997;  99 314-322
    PubMedSearch in Google Scholar
  • 77 Bergmann R L, Edenharter G, Bergmann K E, Guggenmoos-Holzmann I, Forster J, Bauer C P, Wahn V, Zepp F, Wahn U. Predictability of early atopy by cord blood-IgE and parental history.  Clin Exp Allergy. 1997;  27 752-760
    CrossrefPubMedSearch in Google Scholar
  • 78 Wahn V. Differenzialdiagnose kindlicher Immundefekte.  Prädiat Prax. 1998;  55 79-100
    PubMedSearch in Google Scholar
  • 79 Boccagni P, Favari F, Zanoni G, Pezzini A, Tridente G. Comparison of four in vitro assays for specific IgE detection.  Int J Clin Lab Res. 1994;  24 102-105
    CrossrefPubMedSearch in Google Scholar
  • 80 Bjorksten B. Immunological outcome measures.  Eur Respir J Suppl. 1996;  21 22s-27s
    PubMedSearch in Google Scholar
  • 81 Boluda L, Fernandez-Caldas E, Berrens L. The role of IgG in type-I allergy: an unsolved problem.  J Investig Allergol Clin Immunol. 1997;  7 205-210
    PubMedSearch in Google Scholar
  • 82 Galli S J. Mast cells and basophils.  Curr Opin Hematol. 2000;  7 32-39
    CrossrefPubMedSearch in Google Scholar
  • 83 Hammar E, Berglund A, Hedin A, Norrman A, Rustas K, Ytterstrom U, Akerblom E. An immunoassay for histamine based on monoclonal antibodies.  J Immunol Methods. 1990;  128 51-58
    CrossrefPubMedSearch in Google Scholar
  • 84 Brockow K, Vieluf D, Puschel K, Grosch J, Ring J. Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium.  J Allergy Clin Immunol. 1999;  104 237-238
    CrossrefPubMedSearch in Google Scholar
  • 85 Biedermann T, Rueff F, Sander C A, Przybilla B. Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels.  Br J Dermatol. 1999;  141 1110-1112
    CrossrefPubMedSearch in Google Scholar
  • 86 Schwartz L B, Yunginger J W, Miller J, Bokhari R, Dull D. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis.  J Clin Invest. 1989;  83 1551-1555
    CrossrefPubMedSearch in Google Scholar
  • 87 Beyer K, Niggemann B, Schulze S, Wahn U. Serum tryptase and urinary 1-methylhistamine as parameters for monitoring oral food challenges in children.  Int Arch Allergy Immunol. 1994;  104 348-351
    PubMedSearch in Google Scholar
  • 88 Venge P, Bystrom J, Carlson M, Hakansson L, Karawacjzyk M, Peterson C, Seveus L, Trulson A. Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease.  Clin Exp Allergy. 1999;  29 1172-1186
    CrossrefPubMedSearch in Google Scholar
  • 89 Winther L, Moseholm L, Reimert C M, Stahl S P, Kaergaard P L. Basophil histamine release, IgE, eosinophil counts, ECP, and EPX are related to the severity of symptoms in seasonal allergic rhinitis.  Allergy. 1999;  54 436-445
    PubMedSearch in Google Scholar
  • 90 Czech W, Krutmann J, Schopf E, Kapp A. Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis.  Br J Dermatol. 1992;  126 351-355
    PubMedSearch in Google Scholar
  • 91 MacGlashan Jr D W. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables.  J Allergy Clin Immunol. 1993;  91 605-615
    CrossrefPubMedSearch in Google Scholar
  • 92 Kleine-Tebbe J. Basophil histamine release by freshly prepared food extracts.  Allergy Proc. 1993;  14 255-258
    CrossrefPubMedSearch in Google Scholar
  • 93 de Weck A L. Zellulärer Allergen-Stimulierungs-Test (CAST).  Allergologie. 1997;  20 487-502
    PubMedSearch in Google Scholar
  • 94 MacGlashan Jr D W, Peters S P, Warner J, Lichtenstein L M. Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links.  J Immunol. 1986;  136 2231-2239
    PubMedSearch in Google Scholar
  • 95 Kepley C L, Youssef L, Andrews R P, Wilson B S, Oliver J M. Multiple defects in Fc epsilon RI signaling in Syk-deficient nonreleaser basophils and IL-3-induced recovery of Syk expression and secretion.  J Immunol. 2000;  165 5913-5920
    PubMedSearch in Google Scholar
  • 96 Wedi B. In vitro diagnostic of pseudoallergic reactions - new aspects.  ACI Int. 1996;  8 113-115
    PubMedSearch in Google Scholar
  • 97 Cahen Y D, Maly F E, Wuthrich B. Cellular antigen stimulation test (CAST) - applicability in the diagnosis of insect toxin allergies.  Schweiz Med Wochenschr. 1997;  127 5-11
    PubMedSearch in Google Scholar
  • 98 Lebel B, Messaad D, Kvedariene V, Rongier M, Bousquet J, Demoly P. Cysteinyl-leukotriene release test (CAST) in the diagnosis of immediate drug reactions.  Allergy. 2001;  56 688-692
    CrossrefPubMedSearch in Google Scholar
  • 99 Knol E F, Mul F P, Jansen H, Calafat J, Roos D. Monitoring human basophil activation via CD63 monoclonal antibody 435.  J Allergy Clin Immunol. 1991;  88 328-338
    CrossrefPubMedSearch in Google Scholar
  • 100 Saporta M, Kamei S, Persi L, Bousquet J, Arnoux B. Basophil activation during pollen season in patients monosensitized to grass pollens.  Allergy. 2001;  56 442-445
    CrossrefPubMedSearch in Google Scholar
  • 101 Sainte-Laudy J, Sabbah A, Drouet M, Lauret M G, Loiry M. Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release.  Clin Exp Allergy. 2000;  30 1166-1171
    CrossrefPubMedSearch in Google Scholar
  • 102 Moneret-Vautrin D A, Sainte-Laudy J, Kanny G, Fremont S. Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy.  Ann Allergy Asthma Immunol. 1999;  82 33-40
    PubMedSearch in Google Scholar
  • 103 Berg P A, Daniel P T, Brattig N. Immunologie und Nachweis medikamentöser Allergien. In: Fuchs E, Schulz KH (eds) Manuale Allergologicum IV. Deisenhofen; Dustri Verlag Dr. Karl Feistle 1996: 1-13
    Search in Google Scholar
  • 104 Hertl M, Merk H F. Lymphocyte activation in cutaneous drug reactions.  J Invest Dermatol. 1995;  105 95S-98S
    CrossrefPubMedSearch in Google Scholar
  • 105 Koponen M, Pichler W J, de Weck A L. T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets.  J Allergy Clin Immunol. 1986;  78 645-652
    CrossrefPubMedSearch in Google Scholar
  • 106 Pichler W J. Der Lymphozytentransformationstest in der Diagnostik von unerwünschten Arzneimittelreaktionen. In: Merk HF (ed) Allergische und pseudoallergische Arzneimittelreaktionen. 1993: 119-130
    Search in Google Scholar
  • 107 Stejskal V D, Olin R G, Forsbeck M. The lymphocyte transformation test for diagnosis of drug-induced occupational allergy.  J Allergy Clin Immunol. 1986;  77 411-426
    CrossrefPubMedSearch in Google Scholar
  • 108 Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler W J. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.  J Immunol. 1995;  155 462-472
    PubMedSearch in Google Scholar
  • 109 May A, Weber A, Gall H, Kaufmann R, Zollner T M. Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance.  Clin Exp Allergy. 1999;  29 1402-1411
    CrossrefPubMedSearch in Google Scholar
  • 110 Nyfeler B, Pichler W J. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity.  Clin Exp Allergy. 1997;  27 175-181
    CrossrefPubMedSearch in Google Scholar
  • 111 Kondo N, Agata H, Fukutomi O, Motoyoshi F, Orii T. Lymphocyte responses to food antigens in patients with atopic dermatitis who are sensitive to foods.  J Allergy Clin Immunol. 1990;  86 253-260
    CrossrefPubMedSearch in Google Scholar
  • 112 Werfel T, Ahlers G, Schmidt P, Boeker M, Kapp A. Detection of a kappa-casein-specific lymphocyte response in milk-responsive atopic dermatitis.  Clin Exp Allergy. 1996;  26 1380-1386
    CrossrefPubMedSearch in Google Scholar
  • 113 Werfel T, Ahlers G, Schmidt P, Boeker M, Kapp A, Neumann C. Milk-responsive atopic dermatitis is associated with a casein-specific lymphocyte response in adolescent and adult patients.  J Allergy Clin Immunol. 1997;  99 124-133
    PubMedSearch in Google Scholar
  • 114 Wistokat-Wulfing A, Schmidt P, Darsow U, Ring J, Kapp A, Werfel T. Atopy patch test reactions are associated with T lymphocyte-mediated allergen-specific immune responses in atopic dermatitis.  Clin Exp Allergy. 1999;  29 513-521
    CrossrefPubMedSearch in Google Scholar
  • 115 Karplus T E, Ulevitch R J, Wilson C B. A new method for reduction of endotoxin contamination from protein solutions.  J Immunol Methods. 1987;  105 211-220
    CrossrefPubMedSearch in Google Scholar
  • 116 Rasanen L, Sainio H, Lehto M, Reunala T. Lymphocyte proliferation test as a diagnostic aid in chromium contact sensitivity.  Contact Dermatitis. 1991;  25 25-29
    CrossrefPubMedSearch in Google Scholar
  • 117 Rasanen L, Tuomi M L. Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis.  Contact Dermatitis. 1992;  27 250-254
    CrossrefPubMedSearch in Google Scholar
  • 118 Werfel T, Hentschel M, Kapp A, Renz H. Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis.  J Immunol. 1997;  158 2500-2505
    PubMedSearch in Google Scholar
  • 119 Schreiber J, Zissel G, Greinert U, Galle J, Schulz K H, Schlaak M, Muller-Quernheim J. Diagnosis of chronic berylliosis.  Pneumologie. 1999;  53 193-198
    PubMedSearch in Google Scholar
  • 120 Cederbrant K, Hultman P, Marcusson J A, Tibbling L. In vitro lymphocyte proliferation as compared to patch test using gold, palladium and nickel.  Int Arch Allergy Immunol. 1997;  112 212-217
    PubMedSearch in Google Scholar
  • 121 Merk H F. In-vitro-Diagnostik bei Arzneimittel-Allergien.  Allergologie. 1988;  11 57-59
    PubMedSearch in Google Scholar
  • 122 Roujeau J C, Albengres E, Moritz S, Piacentino A, Cuny M, Revuz J, Touraine R. Lymphocyte transformation test in drug-induced toxic epidermal necrolysis.  Int Arch Allergy Appl Immunol. 1985;  78 22-24
    PubMedSearch in Google Scholar
  • 123 Merk H F. Arzneimittelallergie: Einfluss des Fremdstoff-Metabolismus.  Allergologie. 1989;  12 171-173
    PubMedSearch in Google Scholar
  • 124 Bodycote J, Wolff S. Metabolic breakdown of [3H]thymidine and the inability to measure human lymphocyte proliferation by incorporation of radioactivity.  Proc Natl Acad Sci U S A. 1986;  83 4749-4753
    CrossrefPubMedSearch in Google Scholar
  • 125 Wells A D, Gudmundsdottir H, Turka L A. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.  J Clin Invest. 1997;  100 3173-3183
    CrossrefPubMedSearch in Google Scholar
  • 126 Boeker M, Werfel T. In vitro Untersuchungen von Antigen- und Allergen-spezifisch aktivierten mononukleären Zellen.  Allergologie. 1994;  17 374-379
    PubMedSearch in Google Scholar
  • 127 Werfel T, Boeker M, Kapp A. Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions.  Allergy. 1997;  52 465-469
    CrossrefPubMedSearch in Google Scholar
  • 128 Abernathy-Carver K J, Sampson H A, Picker L J, Leung D Y. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.  J Clin Invest. 1995;  95 913-918
    CrossrefPubMedSearch in Google Scholar
  • 129 Reekers R, Busche M, Wittmann M, Kapp A, Werfel T. Birch pollen-related foods trigger atopic dermatitis in patients with specific cutaneous T-cell responses to birch pollen antigens.  J Allergy Clin Immunol. 1999;  104 466-472
    CrossrefPubMedSearch in Google Scholar
  • 130 Eigenmann P A, Tropia L, Hauser C. The mucosal adhesion receptor alpha4beta7 integrin is selectively increased in lymphocytes stimulated with beta-lactoglobulin in children allergic to cow’s milk.  J Allergy Clin Immunol. 1999;  103 931-936
    CrossrefPubMedSearch in Google Scholar
  • 131 Klimek L, Malling H J. Die spezifische Immuntherapie (Hyposensibilisierung) bei allergischer Rhinokonjunktivitis. Metaanalyse zu Wirksamkeit und Nebenwirkungen.  HNO. 1999;  47 602-610
    CrossrefPubMedSearch in Google Scholar
  • 132 Klimek L. Die allergenspezifische Immuntherapie (Hyposensibilisierung) Teil 1: Grundlagen und subkutane Applikation.  HNO. 2000;  48 116-122
    PubMedSearch in Google Scholar
  • 133 Fuchs T, Klimek L. Die allergenspezifische Immuntherapie (Hyposensibilisierung) Teil 2.  HNO. 2000;  48 158-164
    CrossrefPubMedSearch in Google Scholar
  • 134 Greiner W, Graf von der Schulenberg J M, Gillissen A. Kosten und Nutzen der Hyposensibilisierung bei allergischem Asthma und Rhinitis.  Gesundh ökon Qual manag. 2002;  7 179-186
    PubMedSearch in Google Scholar
  • 135 Schadlich P K, Brecht J G. Economic evaluation of specific immunotherapy versus symptomatic treatment of allergic rhinitis in Germany.  Pharmacoeconomics. 2000;  17 37-52
    CrossrefPubMedSearch in Google Scholar
  • 136 Moller C, Dreborg S, Ferdousi H A, Halken S, Host A, Jacobsen L, Koivikko A, Koller D Y, Niggemann B, Norberg L A, Urbanek R, Valovirta E, Wahn U. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).  J Allergy Clin Immunol. 2002;  109 251-256
    CrossrefPubMedSearch in Google Scholar
  • 137 Jacobsen L, Niggemann B, Dreborg S, Ferdousi H A, Halken S, Host A, Koivikko A, Norberg L A, Valovirta E, Wahn U, Moller C. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study.  Allergy. 2007;  62 943-948
    CrossrefPubMedSearch in Google Scholar
  • 138 Des R A, Paradis L, Menardo J L, Bouges S, Daures J P, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children.  J Allergy Clin Immunol. 1997;  99 450-453
    PubMedSearch in Google Scholar
  • 139 Purello-D’Ambrosio F, Gangemi S, Merendino R A, Isola S, Puccinelli P, Parmiani S, Ricciardi L. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study.  Clin Exp Allergy. 2001;  31 1295-1302
    CrossrefPubMedSearch in Google Scholar
  • 140 Coombs R R, Gell P GH. The classification of allergic reactions underlying disease.  Clinical Aspects of Immunology. 1963;  317
    PubMedSearch in Google Scholar
  • 141 Klimek L. Labordiagnostik allergischer Erkrankungen.  CME Praktische Fortbildung Hals-Nasen-Ohrenheilkunde . 2007;  1
    PubMedSearch in Google Scholar

Prof. Dr. med. Ludger Klimek

Zentrum für Rhinologie und Allergologie

An den Quellen 10
65183 Wiesbaden

Email: Ludger.Klimek@HNO-Wiesbaden.de