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DOI: 10.1055/s-2007-996187
The Significance of the Na+/K+ Pump for Somatostatin Release
Publication History
1979
1979
Publication Date:
22 April 2008 (online)
Summary
The influence of the Na+/K+ pump on somatostatin secretion from the isolated perfused canine pancreas was investigated. The somatostatin secretion was reversibly increased in response to addition of ouabain (10-5 mol/l) and to omission of extracellular K+, procedures which are known to cause a blockade of the Na+/K+ pump. The stimulatory effect on somatostatin release was abolished during calcium depletion.
The results suggest that the operation of the Na+/K+ pump plays an important role for the somatostatin secretion. The action of the Na+/K+ pump on the secretory function of the D-cells is dependent on the presence of extracellular calcium.
Key-Words
Perfused Pancreas - Somatostatin - Sodium-Potassium - Calcium