The Renal Clearance of Thyroid Hormones in the Isolated Perfused Rat Kidney

F. Adlkofer; H. J. Schurek; H. Sörje

doi:10.1055/s-2007-996301

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Horm Metab Res 1980; 12(8): 400-404
DOI: 10.1055/s-2007-996301

The Renal Clearance of Thyroid Hormones in the Isolated Perfused Rat Kidney

F. Adlkofer, H. J. Schurek¹ , H. Sörje

Medizinische Klinik und Poliklinik und Nuklearmedizinische Abteilung, Klinikum Steglitz der Freien Universität Berlin
¹Department Innere Medizin, Medizinische Hochschule Hannover, Germany

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Publication History

1979

1979

Publication Date:
22 April 2008 (online)

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Summary

The isolated perfused rat kidney was used to study renal handling of thyroid hormones. Substrate enriched protein free perfusates were chosen which allowed the kidneys to perform a normal glomerular filtration rate of 1.1 ml/g kidney · min and enabled accurate estimation of filtered load and tubular handling of free thyroid hormones without interference from the presence of hormone binding substances. Under these conditions we found a high tubular reabsorption capacity for both T₃ and T₄. This reabsorption capacity was unsaturable, even when the filtered hormone load was far above (× 100) the physiological range.

Key-Words

Isolated Rat Kidney - Protein Free Perfusate - Thyroxine-Triiodothyronine-Clearances of Thyroid Hormones