RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000077.xml
Semin Thromb Hemost 1996; 22(4): 343-345
DOI: 10.1055/s-2007-999029
DOI: 10.1055/s-2007-999029
Synthesis and Study on a Novel Inhibitor of Thrombin Containing No Side Chain at the P1 Position of the Polypeptide Chain
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
06. Februar 2008 (online)
![](https://www.thieme-connect.de/media/sth/199604/lookinside/thumbnails/10.1055-s-2007-999029-1.jpg)
Abstract
The presented work allows one to speculate that the hydrophobic contacts of the residues located at the P2 and P3 positions with the corresponding subsites of thrombin (S2 and S3) allow the synthesis of compounds that can react with thrombin specifically and probably may not interact with other trypsin-like serine proteases. Substitution of proline by m-Abz-residue may result in the development of novel substrates and inhibitors for thrombin.
Keywords:
Thrombin - antithrombin - D-Phe-Pro-Gly-amide - arginine - enzyme inhibition