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Semin Thromb Hemost 1996; 22(4): 357-366
DOI: 10.1055/s-2007-999032
Copyright © 1996 by Thieme Medical Publishers, Inc.

The Influence of C1-Esterase Inhibitor Substitution on Coagulation and Cardiorespiratory Parameters in an Endotoxin-Induced Rabbit Model of Hypercoagulability

Ralf U. Scherer, Reiner M. Giebler, Ulrich Schmidt† , Dietrich Paar‡ , Wolfgang J. Kox§
  • From the Department of Anesthesiology and Intensive Care,
  • †Department of Pathology,
  • ‡Department of Clinical Chemistry and Laboratory Diagnostic, University Hospital Essen, Essen, and
  • §Department of Anesthesiology and Intensive Therapy, University Hospital Charité, Berlin, Germany.
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Publication History

Publication Date:
06 February 2008 (online)

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Abstract

In a short-time model of endotoxininduced (lipopolysaccharide from Escherichia coli, 120 μg kg-1 i.v.) hypercoagulability in rabbits, the therapeutic effects of C1-esterase inhibitor (C1I) substitution (bolus 400 U kg-1 i.v. followed by continuous infusion of 400 U kg-1 4 h-1 i.v.) were studied. When compared to endotoxin-challenged untreated animals, C1I substitution significantly stabilized mean arterial pressure (p < 0.01), increased central venous oxygen saturation (p < 0.05), prevented the decrease of antithrombin III (p < 0.05), and reduced fibrin deposition in the microcirculation of the liver and the lungs to approximately 30% of that observed in the untreated animals (p < 0.01). Although C1I substitution did not reduce systemic procoagulant turnover, the improvement of blood pressure and blood flow and local inhibitory actions in the coagulation and complement cascade prevented fibrin deposition in the microcirculation of vital organs. This study supports the beneficial role of C1I substitution during early disseminated intravascular coagulation.

Keywords:

Endotoxemia - DIC - C1-esterase inhibitor - antithrombin III - blood pressures