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Horm Metab Res 1980; 12(10): 516-519
DOI: 10.1055/s-2007-999189
© Georg Thieme Verlag, Stuttgart · New York

Radioimmunoassayable Serum Somatomedin B in Normal Subjects and in Patients with Acromegaly and Pituitary Dwarfism: Effects of Human Growth Hormone Therapy

B. L. Wajchenberg, B. Liberman, E. N. D. S. Gomes, R. R. Pieroni
  • Diabetes and Adrenal Unit, Hospital das Clinicas; Endocrine Unit - Hospital Brigadeiro INAMPS and Instituto de Pesquisas Energéticas e Nucleares (IPEN), São Paulo, Brazil
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Publication History

1979

1980

Publication Date:
14 March 2008 (online)

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Summary

We report the results obtained with a radioimmunoassay for serum somatomedin B (SmB) in 29 normal subjects, in 33 pituitary dwarfs (GHD) and 6 acromegalic patients. There were no significant differences between the basal SmB levels of the GHD and the normal subjects higher value observed in the acromegalic group (p < 0.01). After acute human growth hormone administration a parallel increase of SmB serum levels and plasma growth hormone was seen (r = 0.562; p < 0.01). Of 12 GHD subjects SmB serum levels increased only in five, after chronic hGH administration.

Key-Words

Somatomedin B - Growth Hormone - Pituitary Dwarfism - Acromegaly