Insulin and adenosine are both antilipolytic when studied in the epinephrine-stimulated
perifused isolated fat cell. Sub-maximal combinations of insulin plus adenosine are
additive but not synergistic. The polypeptide hormone insulin produces an antilipolytic
effect which manifests itself as a “lag” in restoration of epinephrine-stimulated
lipolysis after removal of the insulin. No such lag is observed with the non-peptide,
small molecular weight adenosine. Herein, we demonstrate the antilipolytic effect
of two distinct, physiologically important agents in the perifused isolated fat cell.
Adenosine
-
Insulin
-
Antilipolysis
-
Perifused Fat Cell
-
Hormone Action
