Subscribe to RSS
DOI: 10.1055/s-2007-999234
Effects of Salbutamol and Butoxamine on the Human Fat Cell Adenylate Cyclase
Publication History
1979
1980
Publication Date:
22 April 2008 (online)
![](https://www.thieme-connect.de/media/hmr/198012/lookinside/thumbnails/10.1055-s-2007-999234-1.jpg)
Summary
In order to characterize the β-adrenoceptors coupled to the human fat cell adenylate cyclase more extensively the effects of the β2-selective agonist salbutamol on basal and isoproterenol-stimulated rates of cAMP-accumulation were studied. Although exhibiting only low intrinsic activity salbutamol displayed only slightly lower affinity towards the β-adrenoceptors linked to the human fat cell adenylate cyclase than isoproterenol. In addition, the β2-selective antagonist butoxamine was slightly more potent in inhibiting the isoproterenol-stimulated fat cell enzyme than the cardio-selective β-blocking agent practolol. These results further emphasize the difficulties in classifying the lipolytic response of adipose tissue to β-adrenergic agonists and antagonists within a uniform β-receptor theory.
Key-Words
Human Fat Cell Adenylate Cyclase - Salbutamol - cAMP - Butoxamine