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Am J Perinatol 1990; 7(3): 211-213
DOI: 10.1055/s-2007-999483
ORIGINAL ARTICLE

© 1990 by Thieme Medical Publishers, Inc.

Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

Avirachan T. Tharapel, Michael L. Moretti, Carole M. Meyers, Lee P. Shulman, Robert E. Tipton, John B. Summitt, Sherman Elias, R. Sid Wilroy Jr. , Michael Epps, Joe Leigh Simpson
  • Departments of Pediatrics, Obstetrics and Gynecology, and the Newborn Center, University of Tennessee, Memphis, and Woman's Clinic, Jackson, Tennessee
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multiple fetal anomalies and intrauterine growth retardation.