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Am J Perinatol 1990; 7(4): 356-358
DOI: 10.1055/s-2007-999522
ORIGINAL ARTICLE

© 1990 by Thieme Medical Publishers, Inc.

Alpha-Thalassemia: Prenatal Diagnosis and Neonatal Implications

Mark C. Maberry, Victor R. Klein, Corinne Boehm, Tina C. Warren, Larry C. Gilstrap III 
  • Departments of Obstetrics & Gynecology and Pediatrics, University of Texas Southwestern Medical School, Dallas, Texas, and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Homozygous α-thalassemia major, or Bart's hemoglobinopathy, is the most common etiology of nonimmune hydrops in those of Oriental descent. The prenatal diagnosis can now be made utilizing DNA hybridization technique from fetal cells obtained by either amniocentesis or chorionic villus sampling. A case is reviewed documenting the utilization of DNA studies in managing patients known or suspected to have a history of α-thalassemia major.