ABSTRACT
Micropenis is often an early sign of congenital hypopituitarism. It has also been
associated with congenital adrenal hypoplasia in infants with anencephaly and pituitary
agenesis. This report is on two infants with micropenis and congenital adrenal hypoplasia.
One presented with a similar clinical course and postmortem findings to previously
reported cases of adrenal hypoplasia and pituitary agenesis. The other patient represents
the first reported case of an infant with micropenis and congenital adrenal hypoplasia
in the absence of pituitary agenesis. The histologic patterns of adrenal hypoplasia,
as well as the etiologic and clinical implications of its association with micropenis,
are discussed.
