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Am J Perinatol 1989; 6(3): 307-309
DOI: 10.1055/s-2007-999599
ORIGINAL ARTICLE

© 1989 by Thieme Medical Publishers, Inc.

Recurrent Neonatal Herpes Presenting Initially with Hoarseness

James C. Opitz, Mary Alice Kettrick, Bradley J. Sullivan
  • Departments of Pediatrics and Microbiology, Marshfield Clinic, Marshfield, Wisconsin
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

This report describes a newborn with recurrent herpes simplex meningoencephalitis despite vigorous antiviral therapy. The course is unusual in that the presenting symptom was hoarseness. Despite probable adequate acyclovir levels in the spinal fluid, a second episode or progression of herpetic encephalitis occurred, suggesting impairment of host defenses, particularly cellular immunity. This episode was treated with both acyclovir and vidarabine. Pharmacokinetics of the antiviral therapy and immune responses are discussed.