A Comparison of the Hemodynamic Responses of Systematic and Uteroplacental Vasculature to Angiotensin in Conscious Guinea Pigs

Seemanthini Hariharan; Hsui-yu Tseng; Stephen A. Myers

doi:10.1055/s-2007-999781

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Am J Perinatol 1987; 4(3): 235-239
DOI: 10.1055/s-2007-999781

ORIGINAL ARTICLE

A Comparison of the Hemodynamic Responses of Systematic and Uteroplacental Vasculature to Angiotensin in Conscious Guinea Pigs[1]

Seemanthini Hariharan, Hsui-yu Tseng, Stephen A. Myers

Department of Obstetrics and Gynecology, Michael Reese Hospital and Medical Center, Chicago, Illinois

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Publikationsdatum:
04. März 2008 (online)

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ABSTRACT

Hemodynamic studies were performed in 11 conscious pregnant guinea pigs using radioactive microspheres to calculate the effects of angiotensin II (All) infusion. A dose-dependent increase of the mean arterial pressure and systemic vascular resistance during All infusion was observed. A significant increase in in uteroplacental flow also occurred without a change in cardiac output or uteroplacental vascular resistance. These data demonstrate that the systemic and uterine vasculatures of the pregnant guinea pig have different responses to All infusion.

1 This research was supported by Michael Reese Hospital Research Foundation Grant 7307